What SARS, autoimmune disease and decades of neuroendocrine research can teach us about hypocortisolism — and why ginsenosides deserve a closer look

What SARS, autoimmune disease and decades of neuroendocrine research can teach us about hypocortisolism — and why ginsenosides deserve a closer look

Sleep, circadian timing, mitochondria, red light, Long COVID, ME/CFS and the recent cardiovascular controversy

Can infections leave a lasting imprint on our immune system? Exploring trained immunity and its potential implications for Long COVID, ME/CFS and future vaccines.

From genetics and TORCH infections to maternal autoantibodies, cerebral folate deficiency and the possible lessons from ME/CFS and Long COVID

From genetics and TORCH infections to maternal autoantibodies, cerebral folate deficiency and the possible lessons from ME/CFS and Long COVID

N-acetylcysteine (NAC) is an old mucolytic with a surprisingly modern story: it sits at the crossroads of glutamate, glutathione, mitochondria, oxidative stress and immune regulation.

N-acetylcysteine (NAC) is an old mucolytic with a surprisingly modern story: it sits at the crossroads of glutamate, glutathione, mitochondria, oxidative stress and immune regulation.

New evidence from multiple sclerosis is connecting viral reactivation, HLA genetics, B-cell biology and loss of immune tolerance

New evidence from multiple sclerosis is connecting viral reactivation, HLA genetics, B-cell biology and loss of immune tolerance

A new Phase 2 trial suggests that targeting inflammatory signalling in the brain may help fatigue, cognitive dysfunction and post-exertional malaise in some people with Long COVID

What if histamine is not the disease itself, but one layer of a much larger immune process?

The cholinergic hypothesis is biologically interesting, but the evidence is far more complex than the idea that nicotine simply “displaces Spike” from a receptor

What if histamine is not the disease itself, but one layer of a much larger immune process?

What Long COVID, ME/CFS, autoimmune diseases, fibromyalgia, cancer and post-infectious syndromes may teach us about the shared biology of fatigue

New article about Mestinon (pyridostigmine) in Long COVID and ME/CFS. I look at why it may make physiological sense in some patients with dysautonomia, low preload or impaired autonomic compensation,...

From the Russian flu and the 1918 influenza pandemic to EBV, Q fever, SARS, Ebola and ME/CFS — what history can teach us about why some people never fully recover after infection

Why LDN may make biological sense in some patients — and why comparing it with metformin reveals a bigger problem in how we study post-infectious disease

Why immunosenescence, viral reactivation and chronic immune stimulation may deserve a place in the longevity conversation

From immunometabolism and viral persistence to oxidative stress, endothelial dysfunction and patient selection

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), long COVID (LC) and post-COVID-19 vaccine syndrome show similarities in their pathophysiology...

Objective Following the severe acute respiratory syndrome (SARS) outbreak, many survivors were observed to suffer from psychosomatic symptoms reminiscent of various endocrine disorders. Hence, we so...

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), long COVID (LC) and post-COVID-19 vaccine syndrome show similarities in their pathophysiology...

The prevalence of autoimmune diseases in contemporary human populations poses a challenge for both medicine and evolutionary biology. This review explores ho...

Both myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) and long COVID (LC) are characterized by similar immunological alterations, persistence of chronic viral infection, autoimmunity, ch...

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) affects approximately 1% of the general population. It is a chronic, disabling, multi-system d...