Sleep, circadian timing, mitochondria, red light, Long COVID, ME/CFS and the recent cardiovascular controversy

Can infections leave a lasting imprint on our immune system? Exploring trained immunity and its potential implications for Long COVID, ME/CFS and future vaccines.

From genetics and TORCH infections to maternal autoantibodies, cerebral folate deficiency and the possible lessons from ME/CFS and Long COVID

From genetics and TORCH infections to maternal autoantibodies, cerebral folate deficiency and the possible lessons from ME/CFS and Long COVID

N-acetylcysteine (NAC) is an old mucolytic with a surprisingly modern story: it sits at the crossroads of glutamate, glutathione, mitochondria, oxidative stress and immune regulation.

N-acetylcysteine (NAC) is an old mucolytic with a surprisingly modern story: it sits at the crossroads of glutamate, glutathione, mitochondria, oxidative stress and immune regulation.

New evidence from multiple sclerosis is connecting viral reactivation, HLA genetics, B-cell biology and loss of immune tolerance

New evidence from multiple sclerosis is connecting viral reactivation, HLA genetics, B-cell biology and loss of immune tolerance

A new Phase 2 trial suggests that targeting inflammatory signalling in the brain may help fatigue, cognitive dysfunction and post-exertional malaise in some people with Long COVID

What if histamine is not the disease itself, but one layer of a much larger immune process?

The cholinergic hypothesis is biologically interesting, but the evidence is far more complex than the idea that nicotine simply “displaces Spike” from a receptor

What if histamine is not the disease itself, but one layer of a much larger immune process?

What Long COVID, ME/CFS, autoimmune diseases, fibromyalgia, cancer and post-infectious syndromes may teach us about the shared biology of fatigue

New article about Mestinon (pyridostigmine) in Long COVID and ME/CFS. I look at why it may make physiological sense in some patients with dysautonomia, low preload or impaired autonomic compensation,...

From the Russian flu and the 1918 influenza pandemic to EBV, Q fever, SARS, Ebola and ME/CFS — what history can teach us about why some people never fully recover after infection

Why LDN may make biological sense in some patients — and why comparing it with metformin reveals a bigger problem in how we study post-infectious disease

Why immunosenescence, viral reactivation and chronic immune stimulation may deserve a place in the longevity conversation

From immunometabolism and viral persistence to oxidative stress, endothelial dysfunction and patient selection

Manuel Ruiz-Pablos talks about the science behind HLA-II and chronic inflammation, what he would tell policymakers about investing in ME/CFS research, and his new publication exploring HLA-II haplotyp...

Purpose This review aims to collect and examine recent research findings regarding hypopituitarism and COVID-19, focusing on the virus’s impact on the pituitary gland and the outcomes for infected pat...

Purpose This review aims to collect and examine recent research findings regarding hypopituitarism and COVID-19, focusing on the virus’s impact on the pituitary gland and the outcomes for infected pat...