Reposted by Madeleine Hart
New out this week in @natmetabolism.nature.com – We measured dynamic aspartate changes following mitochondrial inhibition, finding that SDH inhibition causes a counterintuitive "aspartate rebound" effect, mediated by succinate impairing pyrimidine synthesis.
www.nature.com/articles/s42...
nature.com
Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase - Nature Metabolism
Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase (ATCase), leading to impaired pyrimidine biosynthesis and reduced proliferation under SDH inhibition.
