Jen Brain (Crainic) @jenniferabrain.bsky.social · 21/07/2026The best trainee-only metabolism conference! I'll be there for the 4th year in a row!! 010
Reposted by Jen Brain (Crainic)Fred Hutch @fredhutch.org · 23/04/2026That's a wrap on #AACR26! Researchers from Fred Hutch and @uwmedicine.bsky.social were in San Diego at @theaacr.bsky.social Annual Meeting sharing findings in cancer prevention, diagnosis and care — from new insights on #colorectalcancer risk to emerging targets for #ovariancancer and more. 031
Jen Brain (Crainic) @jenniferabrain.bsky.social · 17/04/2026#AACR2026 kicks off this weekend! Come find me at my posters! 🧪 Constitutive NRF2 activation drives excess cysteine stress 🗓️ April 19th, 2-5pm 📍Section 22, Board 3 🧪 Cysteine as a driver of resistance to Bortezomib 🗓️ April 20th, 9am-12pm 📍Section 16, Board 8 010
Jen Brain (Crainic) @jenniferabrain.bsky.social · 13/04/2026Just landed in Cincinnati for the first annual Future Faculty Conference hosted by the University of Cincinnati Cancer Center. Grateful for the invitation to grow my network, attend workshops for professional development, and meet with potential mentors and collaborators! 020
Reposted by Jen Brain (Crainic)Lucas Sullivan @lucasbsullivan.bsky.social · 08/04/2026Also, check out this great N&V write up from the PapaG lab: www.nature.com/articles/s42...nature.comDrowning in cysteine - Nature MetabolismIn this issue of Nature Metabolism, Brain, Vigil et al. show that NRF2-induced cystine uptake drives the formation of several cysteine–sugar metabolites. This process acts as a ‘sink’ for free cystein... 061
Reposted by Jen Brain (Crainic)Lucas Sullivan @lucasbsullivan.bsky.social · 08/04/2026Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go? 25023
Reposted by Jen Brain (Crainic)Nature Metabolism @natmetabolism.nature.com · 07/04/2026dlvr.itDrowning in cysteineNature Metabolism, Published online: 07 April 2026; doi:10.1038/s42255-026-01511-1In this issue of Nature Metabolism, Brain, Vigil et al. show that NRF2-induced cystine uptake drives the formation of several cysteine–sugar metabolites. This process acts as a ‘sink’ for free cysteine and can lead to metabolic vulnerabilities and toxicity in NRF2-activated tumours. 0156
Jen Brain (Crainic) @jenniferabrain.bsky.social · 07/04/2026Check out our latest work out today in @natmetabolism.nature.com in which we describe a new metabotype (metabolic phenotype): excess cysteine stress. We discovered novel cysteine conjugates and show how pyruvate modulates free intracellular cysteine levels. Grateful for an awesome team!! 1136
Jen Brain (Crainic) @jenniferabrain.bsky.social · 25/04/2025Overjoyed to have the opportunity to present my work orally at the Cancer Metabolism Showcase! Hope to see you there virtually! 052
Reposted by Jen Brain (Crainic)Jeremy Berg @jeremymberg.bsky.social · 24/04/2025ATTENTION: NSF GRANT RECIPIENTS We received a heads up from a trusted source that you should proactively download/print/screen shot any documentation on research.gov pertaining to your NSF awards, both those that are current and any that have closed in the last 5-6 years. 1/nmedia.tenor.coma cartoon of a man holding a frying pan and a spoon with red alert written above himALT: a cartoon of a man holding a frying pan and a spoon with red alert written above him 251038917
Jen Brain (Crainic) @jenniferabrain.bsky.social · 03/04/2025Obliteride registeration opens today!!! Join the @lucasbsullivan.bsky.social team and help to CURE CANCER FASTER! See you August 9th at the starting line!! @obliteride.bsky.social #Obliteride #Obliteride2025 secure.fredhutch.org/goto/sulliva... 022
Jen Brain (Crainic) @jenniferabrain.bsky.social · 13/03/2025Poster is printed! Looking forward to going to the Keystone Tumor Metabolism meeting next week in Vancouver. Come talk to me about NRF2, cysteine, and novel metabolite discovery! #KSTumorMetab25 #cancermetabolism #keystonesymposia 0111