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Mackinder Lab

@mackinderlab.bsky.social
71 followers 41 following 2 posts

Molecular basis of global carbon fixation. Algal tool development. Pyrenoids. LLPS.

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Florent Waltz @florentwaltz.bsky.social · 05/10/2026
Huge congratulations to all three Nobel Laureates, and especially Peter Hegemann! 👏 His seminal work on the green alga Chlamydomonas 🦠 laid the foundation for optogenetics. Thank you for putting Chlamy in the spotlight! ✨ Proof that groundbreaking discoveries don't always come from animal models! 🔬
Chlamydomonas cells
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Glen Wheeler @glwheeler2.bsky.social · 05/10/2026
Fantastic to see the Nobel Prize awarded for the discovery of channelrhodopsin which arose from Peter Hegemann's studies of algal motility. Here is a Chlamydomonas cell celebrating with some flagella calcium signals!
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Jamie Blaza @jnb-lab.bsky.social · 17/08/2026
Our preprint is now published!
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Mackinder Lab @mackinderlab.bsky.social · 12/08/2026
Thanks Noam. It wouldn’t have been possible without my amazing team and all the support and guidance from my mentors, colleagues and the University of York!
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Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
jobs.york.ac.uk
Jobs - The University of York
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Florent Waltz @florentwaltz.bsky.social · 27/07/2026
This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏
nature.com
Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants
Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...
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Silvia Ramundo @sramundo.bsky.social · 24/06/2026
1/7 New preprint: we found that Chlamydomonas carries a giant and unexpectedly elaborate chloroplast RNA polymerase with 12 previously unknown subunits, overturning the idea that the complexity of this organellar enzyme emerged during plant terrestrialization! www.biorxiv.org/content/10.6...
biorxiv.org
The structure of a 2-MDa chloroplast RNA polymerase reveals unexpected evolutionary complexity
Transcription in chloroplasts depends on the Plastid-Encoded RNA polymerase (PEP), a bacterial-derived enzyme whose catalytic core remains encoded by the highly reduced genome inherited from the cyano...
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Ben Engel @cellarchlab.com · 22/07/2026
It’s a pyrenoid party! 🪩🌍 Awesome collab🤝 of @phaips.vd.st & @manondemulder.bsky.social with Mihris and the @mackinderlab.bsky.social crew to reveal the molecular architecture🏗️ of the Chorella pyrenoid. Algae have so many convergently evolved compartments to supercharge #CO2 capture. #TeamTomo 🔬🌾🌊🧪
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Tanner Robison @tarobison.bsky.social · 22/07/2026
Another day, another cool paper from @mackinderlab.bsky.social @james-r-barrett.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Molecular organization of the Chlorella sorokiniana pyrenoid
To overcome the enzymatic limitations of Rubisco, algae operate CO2-concentrating mechanisms (CCMs) that deliver concentrated CO2 to Rubisco tightly packaged in a specialized microcompartment called a...
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Mihris Naduthodi @mihrisn.bsky.social · 22/07/2026
(1/16) Nearly two-thirds of ocean carbon fixation flows through a diverse organelle: the pyrenoid. Our new paper maps its 3D architecture in the alga Chlorella and identifies new proteins — expanding the toolkit to engineer this CO2-concentrating machine into crops🧵 #Pyrenoid #CCM #Photosynthesis
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Mackinder Lab @mackinderlab.bsky.social · 26/07/2026
Another pyrenoid, another example of convergent evolution to condense Rubisco and turbocharge photosynthesis. This time in a multicellular organism. So much fun exploring a seaweed pyrenoid with @jonasblomme.bsky.social, @mjplevin.bsky.social, @jnb-lab.bsky.social, @james-r-barrett.bsky.social.
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 30/01/2026
Check out this cool thread on the latest preprint by Gaurav Kumar, @james-r-barrett.bsky.social, @phaips.vd.st from our lab and colleagues, dissecting the physics of Rubisco condensates! You're in for some stunning #cryoET of the pyrenoid - in Chlamy, of course 😉 Congrats to all involved!
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Florent Waltz @florentwaltz.bsky.social · 30/01/2026
Check this new study on carbon concentration mechanisms! See how the pyrenoid changes by modifying Rubisco linkers in our favorite alga, Chlamy 💚! My desk mate @phaips.vd.st spent a lot of time collecting & carefully analyzing these beautiful tomograms 🔬. Congrats to all the authors!
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Ben Engel @cellarchlab.com · 30/01/2026
That is a really beautiful poster!🤩 🧪 Inside the Pyrenoid: How Multivalency Shapes Rubisco Organization and CO2 Fixation www.biorxiv.org/content/10.6...
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Philippe Van der Stappen @phaips.vd.st · 30/01/2026
You like #LLPS? #TeamTomo? #Rubisco? Check out our latest preprint! What a great collaboration this has been!
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James Barrett @james-r-barrett.bsky.social · 30/01/2026
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid
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