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Lou-Downs

@lou-downs.bsky.social
100 followers 33 following 5 posts

Infectious diseases clinician living in beautiful Kenya 🇰🇪 Working to improve healthcare services for those living with hepatitis B infection 🦠

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Philippa Matthews @pippa-matt.bsky.social · 26/09/2025
Scientific, public health & lived experience rationale for expanding #hepatitis B treatment. Webinar hosted by @ice-hbv.bsky.social & #HepatitisBFoundation. Details in flyer 👇 #HBV #HepSky #LiverSky #MedSky 🧪💊🌍 @suwang88.bsky.social @lancetgastrohep.bsky.social www.hepb.org
Flyer for webinar on hepatitis B treatment, scheduled for Oct 23 205 4pm EDT.
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Philippa Matthews @pippa-matt.bsky.social · 25/09/2025
Shout out to @lou-downs.bsky.social & Dorcas Okanda for a prize at #COLDA. Their #HBV work in #Kenya expands insights in a neglected space, using #virus #genomics to influence healthcare. #MedSky #NoHep @crick.ac.uk @ndm.ox.ac.uk @ucl.ac.uk @wellcometrust.bsky.social @kemriwellcome.bsky.social 🧪🇰🇪🌍
Photo of Dorcas and Louise with first prize certificatePhoto of members of the Matthews group for hepatitis elimination at COLDA in Accra, Ghana 🇬🇭
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Philippa Matthews @pippa-matt.bsky.social · 13/09/2025
Work by @mariondelphin.bsky.social & @tongaimaponga.bsky.social to describe #immune signatures associated with diverse treatment outcomes in #HBV infection. #hepatitis #immunology #LiverSky #MedSky 🧪 @crick.ac.uk @suhealthsci.bsky.social @ucllifesciences.bsky.social doi.org/10.6084/m9.f...
doi.org
Immune activation correlates with viral persistence in individuals living with HBV in South Africa
This poster was presented at HBV meeting 2025
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Philippa Matthews @pippa-matt.bsky.social · 11/04/2025
My original post doesn't show our paper in @lancetmicrobe.bsky.social ...hoping @bsky.app/ @support.bsky.team will fix this... in the meantime here is a thumbnail (link in thread above). #NoHep #HBV #HepSky #GastroSky
Screen shot of a paper at Lancet Microbe "Hepatitis B virus resistance to necleos(t)ide analogue therapy: WHO consultation on questions, challenges, and a roadmap for the field" by Sheila Lumley et al.
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Philippa Matthews @pippa-matt.bsky.social · 07/03/2025
Our team led by @lou-downs.bsky.social has been studying new #biomarkers for #HBV to support wider access to assessment and #treatment. New data from KWTRP in Kenya using a point-of-care test. @wellcometrust.bsky.social 🧪🌍🇰🇪 #NoHep #HepSky #LiverSky #MedSky doi.org/10.1093/ofid...
doi.org
Hepatitis B core-related antigen (HBcrAg) point-of-care tests as a risk stratification tool for treatment eligibility: experience from Kenya
Abstract. We undertook a point-of-care test (POCT) for hepatitis B core-related antigen (HBcrAg) on adults living with HBV in Kilifi, Kenya. A positive tes
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Emily Martyn @emilymartyn.bsky.social · 19/03/2025
Fill out this survey on the impact of US gov changes on hepatitis B care where you are. #GHS2025 #liversky
docs.google.com
'Plan-B': Impact of changes in the global funding landscape for Hepatitis B clinical and research programmes
We are a team of clinicians and researchers based at the Francis Crick Institute in London, and working with international partners and collaborators to advance progress towards hepatitis B eliminatio...
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Emily Martyn @emilymartyn.bsky.social · 19/03/2025
Fab talk by @mariondelphin.bsky.social describing an interesting immune signal for non-viral suppression following nucleotide analogue treatment in people living with hepatitis B in South Africa. #HepSky #LiverSky #GHS2025
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The Lancet Gastroenterology & Hepatology @lancetgastrohep.bsky.social · 14/03/2025
New research - Vincent et al - Hepatitis B core-related antigen rapid diagnostic test for point-of-care identification of women at high risk of hepatitis B vertical transmission: a multicountry diagnostic accuracy study www.thelancet.com/journals/lan... #LiverSky #MedSky #HepSky #IDSky
thelancet.com
Hepatitis B core-related antigen rapid diagnostic test for point-of-care identification of women at high risk of hepatitis B vertical transmission: a multicountry diagnostic accuracy study
HBcrAg-RDT might offer a practical solution for integrating the prevention of vertical transmission of HBV into decentralised antenatal care in resource-limited settings, enabling timely identificatio...
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The Lancet @thelancet.com · 02/03/2025
✨ Exciting new Lancet role ✨ This autumn, our Group is launching an OA journal dedicated to the unique health challenges on the African continent: The Lancet Regional Health—Africa 🌍 To lead this important endeavour, we are searching for an Editor-in-Chief. Find out more & apply ⤵️ bit.ly/3Xp919w
bit.ly
Editor-in-Chief, The Lancet Regional Health - Africa
Do you enjoy using science to drive change in the world? Would you like to develop and launch an online-only gold open access journal for The Lancet. About our Team The Lancet Regional Health -Africa ...
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Lou-Downs @lou-downs.bsky.social · 08/03/2025
Also celebrating our wonderful leader and mentor @pippa-matt.bsky.social who brought us together and continues to inspire us daily with her passion, determination and vision. #InternationalWomensDay #WomenInSTEM #nohep @crick.ac.uk
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Lou-Downs @lou-downs.bsky.social · 08/03/2025
Read about how we have been investigating the use of a new point of care test in #HBV at #kemri-wellcome trust, kilifi and how it may help differentiate those with liver disease and high viral loads #Kenya @wellcometrust.bsky.social @ndm.ox.ac.uk
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Hepatitis SA @hepatitissa.asn.au · 21/02/2025
Pathogens don't obey presidents or pollies. @worldhepalliance.bsky.social @suwang88.bsky.social @hepctrust.bsky.social @endhepcsf.bsky.social @hepatitisfund.bsky.social @thatliverguy.bsky.social hepatitissa.asn.au/communitynew...
hepatitissa.asn.au
Pathogens Don’t Defer to Presidents or Politicians | HepSA Community News
The sudden freezing of USAID funds is jeopardising the goal of eliminating viral hepatitis by 2030. In an editorial published 14 February, the Lancet Gastroenterology & Hepatology said efforts to …
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NEJM.org @nejm.org · 12/02/2025
Perspective by Eleanor R. Menzin, MD: With U.S. politics threatening to erase the gains of science, reduce access to vaccines, and undermine their vast public health benefit, what is a conscientious pediatrician to do? Read the full Perspective: nej.md/4iZNHQW
Square image with a purple background and a quote from a Perspective article by Eleanor R. Menzin, M.D., that reads "Some will ask, “Can you recommend a good pediatrician who does not believe in vaccines?” No, I say, no more than I can recommend a good physicist who does not believe in gravity." At the bottom of the image is "NEJM" next to the logo for the New England Journal of Medicine.
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Lou-Downs @lou-downs.bsky.social · 16/02/2025
“We must not lose sight of the fact that globally, more than 300 million people are living with hepatitis B and C, and as many people die from these infections as from tuberculosis every year.” Stark reminders from @lancetgastrohep.bsky.social on the need to continue HBV and HCV elimination plans
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Philippa Matthews @pippa-matt.bsky.social · 15/02/2025
US policy changes put elimination of viral #hepatitis at high risk. Diagnosis, treatment & prevention all threatened. This affects all of us… don’t look away. #HepSky #MedSky #CDC #USAID @gavi.org @who.int @lancetgastrohep.bsky.social @robbrierley.bsky.social www.thelancet.com/journals/lan...
thelancet.com
US policy changes put elimination of viral hepatitis at high risk
Sparked by a flurry of executive orders in the first week of taking power, and evolving at dizzying pace, the new US administration has taken a wrecking ball to health-related services and research bo...
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Philippa Matthews @pippa-matt.bsky.social · 15/02/2025
Keep saying it: "U=U" This sign from Kilifi says it well: 'sleeping viruses are not contagious'. By treating #HIV and #HBV in individuals, we also protect communities. Access to medicines keeps everyone safe. 💊🌍 @lou-downs.bsky.social @who.int #USAID #PEPFAR #NoHep #MedSky #IDSky #HepSky #KWTRP
Clinic sign which says U=U followed by explanation in Kiswahili text
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HepB Cant Wait @suwang88.bsky.social · 16/02/2025
Thanks to @contagionlive.bsky.social for the 2 part interview on our piece “Pathogens don’t respect Politicians” published in @thelancet.bsky.social. We must be ready for the fallout from this attack on #GlobalHealth 😥🦠🤕 @pippa-matt.bsky.social @robbrierley.bsky.social @treatmentactiongroup.org
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Matthew Hodson @matthewhodson.bsky.social · 08/02/2025
For the past 21 years the U.S. through PEPFAR has:  👉 Enabled 5.5 million babies to be born HIV-free 👉 Provided 20 million people with lifesaving HIV treatment 👉 Supported 7 million orphans and vulnerable children. Ending this support will end lives. #SaveHIVFunding www.unaids.org/en/topic/PEP...
If PEPFAR were permanently halted UNAIDS estimates that there would be approximately
6.3 million more AIDS related deaths
3.4 million AIDS orphans
8.7 million new HIV adult infections
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HepB Cant Wait @suwang88.bsky.social · 06/02/2025
👇Our just published letter on the sudden sabotage of disease control & public health from the current US administration. “The current catastrophic threat to global health must be stopped.” @lancetgastrohep.bsky.social @pippa-matt.bsky.social @treatmentactiongroup.org @worldhepalliance.bsky.social
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Lou-Downs @lou-downs.bsky.social · 07/02/2025
Pathogens don't respect politicians: US federal disruption poses a new threat to global public health - The Lancet Gastroenterology & Hepatology www.thelancet.com/journals/lan...
thelancet.com
Pathogens don't respect politicians: US federal disruption poses a new threat to global public health
We are facing a new threat to global health.
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Lou-Downs @lou-downs.bsky.social · 29/12/2024
The costs of living with chronic #HBV infection must be considered in any elimination plan. www.thelancet.com/journals/lan.... We need affordable, accessible diagnostics and treatment as a matter of priority @pippa-matt.bsky.social @thelancet.bsky.social
thelancet.com
Elimination of hepatitis B requires recognition of catastrophic costs for patients and their families
In addition to goals of reducing tuberculosis incidence by 80% and tuberculosis deaths by 90% worldwide by 2030, the WHO End TB Strategy aims to eliminate catastrophic costs—defined as out-of-pocket expenses that exceed 20% of annual household income—for households affected by tuberculosis by 2030.1 In this Comment, we consider this concept for people living with hepatitis B.
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