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Long Pan

@longpan.bsky.social

Postdoc @Trevor’s lab @icr.ac.uk, PhD@ zucmanlab.com | Computational biologist/General surgeon | interested in cancer evolution and cell plasticity in Gastrointestinal cancer, keep curiosity!

Posts Replies Media

Long Pan @longpan.bsky.social · 23/05/2026

Overall, our study provides a robust molecular classification for HCC and supports the development of genome-based precision medicine in HCC.

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Long Pan @longpan.bsky.social · 23/05/2026

Integrateing clinical data with clonal evolution analysis, we proposed an evolutionary model for the rare TP53+CTNNB1ex3 subtype, highlighting stepwise selection (TP53 --> CTNNB1), transcriptomic state swiching and its link to poor prognosis.

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Long Pan @longpan.bsky.social · 23/05/2026

Using developed p53 and β-catenin activity scores, we uncovered functional TP53 inactivation BAP1-mutated HCC, validated in mouse models. We also found both AXIN1 and TP53 mutations were associated with increased β-catenin activity and decreased p53 activity.

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Long Pan @longpan.bsky.social · 23/05/2026

Comprehensive annotation of mutations, CNAs, SVs, gene fusions and viral insertion, together with transcriptome identify 9 robust subtypes. 7 out of 9 subtypes were driven by driver gene alterations, suggesting the strong heritability in controlling phenotypic plasticity in HCC.

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Long Pan @longpan.bsky.social · 23/05/2026

Overall, our study provides a robust molecular classification for HCC and supports the development of genome-based precision medicine in HCC.

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Long Pan @longpan.bsky.social · 23/05/2026

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Long Pan @longpan.bsky.social · 23/05/2026

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Long Pan @longpan.bsky.social · 23/05/2026

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