iiinova — where your digital self keeps evolving

loic-yengo.bsky.social @loic-yengo.bsky.social · 11/09/2026

Two years in Brisbane, working on interesting problems with a great team — not a bad way to spend a postdoc! Please apply (link above and below) if that resonates with you or share this with someone who might be interested. Thank you! Link: uq.wd3.myworkdayjobs.com/en-GB/uqcare...

uq.wd3.myworkdayjobs.com

Postdoctoral Research Fellow/Research Fellow in Statistical Genomics

Institute for Molecular Bioscience Full-time fixed-term position for up to 2.5 years Base salary will be in the range $106,293.57 - $113,659.72 + 17% super (Academic Level A) or $119,462.94 - $141,545...

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loic-yengo.bsky.social @loic-yengo.bsky.social · 11/09/2026

Our lab works across a range of areas, including: 🧬 Genetic epidemiology of common diseases. 📊 Quantitative and population genetics, including studies of natural selection 🤖 Integration of omics foundation models with GWAS and statistical genetics

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loic-yengo.bsky.social @loic-yengo.bsky.social · 11/09/2026

The successful applicant will contribute to several projects supported by Snow Medical, with a broad goal of improving the generalisation of genetic findings across diverse contexts — including ancestry, cell types, cellular states and across diseases.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 11/09/2026

This is particularly well suited to someone who is looking to develop their own research programme and build an independent lab over the next 5 years.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 11/09/2026

I’m currently recruiting an experienced postdoc to join our team in Brisbane for at least two years, working on some cutting-edge problems in statistical genomics and genetic epidemiology. Link: uq.wd3.myworkdayjobs.com/en-GB/uqcare...

uq.wd3.myworkdayjobs.com

Postdoctoral Research Fellow/Research Fellow in Statistical Genomics

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loic-yengo.bsky.social @loic-yengo.bsky.social · 11/08/2026

[PhD project available] Applications are closing at the end of the month so please reach out by the end of next week to allow time for interviews. We look forward to hearing from you! Thanks to those who already contacted us.

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Reposted by @loic-yengo.bsky.social

loic-yengo.bsky.social @loic-yengo.bsky.social · 21/07/2026

Come and join our dream team! We’re recruiting a PhD candidate with a strong background in statistics, machine learning and (human) genetics to work at the interface of biological sequence foundational models and scores polygenic score methods.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 03/08/2026

It would have been fantastic to have @dailylaufey.bsky.social among our participants 😀 during her memorable Australian tour! One can still dream...

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loic-yengo.bsky.social @loic-yengo.bsky.social · 03/08/2026

Are you of mixed European and Asian heritage? Well, you may be able to help us make genetic discoveries that can benefit people from all populations. For that, please join The Australian DNA Bridge, a research study focused on people with mixed ancestry like yours. www.youtube.com/watch?v=Oyr3...

youtube.com

DNA BRIDGE - What's Involved?

YouTube video by HSU Projects

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loic-yengo.bsky.social @loic-yengo.bsky.social · 21/07/2026

The project will be co-supervised by my amazing colleague @bradbalderson.bsky.social and I.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 21/07/2026

The PhD project will start during the first quarter of 2027. EOI for Australia-based candidates are due by 31 Aug 2026. More details here: study.uq.edu.au/study-option....

study.uq.edu.au

DNA sequence deep learning to map genome-wide genetic variants underlying complex traits and disease

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loic-yengo.bsky.social @loic-yengo.bsky.social · 21/07/2026

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loic-yengo.bsky.social @loic-yengo.bsky.social · 17/03/2026

👉 Please reach out if you would like to contribute to our study and help us build a more equitable future in healthcare. [web: australiandnabridgestudy.org ] [screen: hsu.imb.uq.edu.au/content/bdg-... ]

hsu.imb.uq.edu.au

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loic-yengo.bsky.social @loic-yengo.bsky.social · 17/03/2026

So, today we launch The Australian DNA Bridge, the first Australia-based study focused on individuals with mixed ancestries. This study will help us make new genetic discoveries that are more accurate, inclusive, and equitable across all populations. [australiandnabridgestudy.org]

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loic-yengo.bsky.social @loic-yengo.bsky.social · 17/03/2026

Today's genetic discoveries aren't equally applicable to everyone. Most of our findings still come from people of predominantly European ancestry, creating large gaps in who might benefit. Our research team is working to address this imbalance!

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loic-yengo.bsky.social @loic-yengo.bsky.social · 17/03/2026

Today we launch The Australian DNA Bridge, a study focused on individuals with mixed ancestries to help us make genetic discoveries that are more accurate, inclusive, and equitable across all populations. Want to learn more? Follow the link. [australiandnabridgestudy.org]

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loic-yengo.bsky.social @loic-yengo.bsky.social · 16/03/2026

Day #1 of The Australian DNA Bridge Study! More in a few hours...Stay tuned.

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Reposted by @loic-yengo.bsky.social

Abdel Abdellaoui @dr-appie.bsky.social · 10/03/2026

If you're looking to build or deepen your knowledge in statistical genetics, the ISG Workshop (June 1–11) covers the full range: biometrics, GWAS, polygenic scores, causal inference, and more. Open to all levels, virtual, and international: www.colorado.edu/ibg/workshop... Retweets appreciated 🙏

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loic-yengo.bsky.social @loic-yengo.bsky.social · 08/02/2026

Excited to start our UK Biobank Symposium week! Today we welcome 90 participants for our 1.5-day workshop covering various statistical genetics methods and applications to UK Biobank data. The UK Biobank Symposium starts on Wednesday...stay tuned. More here: ausukb.org

ausukb.org

2nd Australian UK Biobank Research Symposium - AusUKB

The 2nd Australian UK Biobank Research Symposium is a premier event bringing together leading experts in health, genomics, and epidemiology to explore the transformative power of the UK Biobank. Held ...

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

Well, you know me, Michel 😎! Haha, I've been planning to set an account for some time and thought that was a good opportunity to share our work here too. Seems like the post is well received. Thanks for sharing it.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

10/10 – What now? Well, there are still a few gaps, and I invite anyone to read our comprehensive discussion. In particular, I’d like to point out our LD score regression analysis predicting how much heritability is captured by T2T genome builds but currently missed by hg38.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

9/10 – We release 95% credible sets for the 12,000 loci identified in our WGS-based GWAS.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

8/10 – We compared WGS-based and imputation-based GWAS and show a few interesting examples of common haplotypes that seem to be missing from existing imputation panels (e.g., TOPMed).

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

7/10 – We GWASed all 34 traits, identified ~12,000 significant loci across traits and confirm the strong colocalization between rare- and common-variant associations. In fact, rare-variant detection was best predicted by the presence of a common-variant association within 100 kb.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

6/10 – Genetic correlations (between traits) were largely consistent between common and rare variants.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

5/10 - On average across traits, WGS accounts for 88% of pedigree-based heritability.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

4/10 – For 15/34 traits, we show no significant difference between WGS- and family-based estimates of narrow sense heritability (= additive genetic effects) from within the UK Biobank (thus minimizing the effect of differential measurement errors and phenotype definitions).

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

3/10 – On average across traits, we estimate that ~23% of our estimated WGS-based heritability is due to rare variants (0.01%<frequency<1%). We also show that coding and non-coding genetic variants account for 21% and 79% of rare-variant WGS-based heritability, respectively.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

2/10 – We used the latest release of WGS data in the UK Biobank to produce high-precision estimates of heritability (standard error ~1%) for 34 phenotypes (incl. 4 common diseases). Our analyses include both common (frequency >1%) and rare variants (1%>frequency>0.01%).

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

1/10 - How much of the heritability estimated with family data can we explain using modern genomic technologies? This question has remained open for more than 15 years! Previous studies have used WGS data from TOPMed answer it but sample sizes and sets of traits remained limited.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

My last “Thank You” goes to my colleague, friend and mentor Peter Visscher (who doesn’t hang out here) for inspiring me and many others in the field to work on such a fascinating topic. And now for the science…

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

First of all, a huge "Thank You" to our collaborators at Illumina and to all UK Biobank participants. Also, thanks to many colleagues in the fields for stimulating conversation around this topic. Working on this piece has been an amazing ride!

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

nature.com

Estimation and mapping of the missing heritability of human phenotypes - Nature

WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...

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