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Lioba Berndt

@liobanause.bsky.social
195 followers 479 following 7 posts

RA in Computational Psychiatry & Neuropharmacological Systems‬ • MSc Clinical Neuroscience • BSc Psychology

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Lioba Berndt @liobanause.bsky.social · 06/08/2025
We’re now busily back-translating to mice to test these predictions alongside some drugs that might help. 🐁
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Lioba Berndt @liobanause.bsky.social · 06/08/2025
In-silico pharmacological modelling suggests increasing NMDA receptor gain as a potential therapeutic target, implying NMDA receptor hypofunction as a key driver of sleep alterations in these high-risk individuals.
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Lioba Berndt @liobanause.bsky.social · 06/08/2025
We combine sleep EEG (recorded in the comfort of people’s homes) with Dynamic Causal Modeling to flag mechanisms of synaptic pathology in young people at risk of psychiatric disorders.
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Lioba Berndt @liobanause.bsky.social · 06/08/2025
🧠 New pre-print out: doi.org/10.1101/2025...
doi.org
Sleep as a window into thalamocortical pathology: generative modeling implicates NMDA receptor hypofunction in 22q11.2 deletion syndrome
Background: 22q11.2 deletion syndrome (22q11.2DS) is a strong genetic risk factor for neuropsychiatric conditions, including schizophrenia, autism, ADHD, and intellectual disability. Sleep disturbance...
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Lioba Berndt @liobanause.bsky.social · 20/06/2025
Huge thanks to everyone that made this project possible: Daisy Crawley, Lana Tymchyk, Anna Hall, Jakub Onysk, Tore Erdmann, Elliot Wimmer @elliottwimmer.bsky.social, Isabel Berwian, Agnes Norbury @agnesnorbury.bsky.social and Quentin Huys @docqhuys.bsky.social!
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Lioba Berndt @liobanause.bsky.social · 20/06/2025
New preprint: How does Behavioral Activation help with anhedonia in depression? Our new study finds that early reductions in aversive Pavlovian Bias mediate symptom improvement - suggesting a specific cognitive mechanism in realistic treatment settings. Read more here: doi.org/10.31234/osf...
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Lioba Berndt @liobanause.bsky.social · 10/12/2024
I think this paper explains the concept of Computational Psychiatry really well: doi.org/10.1038/nn.4...
doi.org
Computational psychiatry as a bridge from neuroscience to clinical applications - Nature Neuroscience
The complexity of problems and data in psychiatry requires powerful computational approaches. Computational psychiatry is an emerging field encompassing mechanistic theory-driven models and theoretica...
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Reposted by Lioba Berndt
judewells.bsky.social @judewells.bsky.social · 18/11/2024
Our recent work TED: The Encyclopedia of Domains showcased by UCL: 365 million domain like structures identified in the AlphaFold DB, 194 million with proposed assignments to CATH superfamilies, plus a catalogue of domain-domain interactions. www.ucl.ac.uk/computer-sci...
ucl.ac.uk
UCL-led research reveals new protein map with potential to transform disease research
UCL researchers have developed The Encyclopedia of Domains (TED), a tool mapping millions of unknown protein regions, with potential for breakthroughs in drug discovery and disease research.
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