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Liam Holt

@liamholt.bsky.social

704 followers 146 following 10 posts

What does it feel like in a cell? SciComm, Art, Mental Health ScienceSketches.org

Posts Replies Media

Liam Holt @liamholt.bsky.social · 05/03/2026

Oops. Here's the direct link: authors.elsevier.com/sd/article/S...

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Liam Holt @liamholt.bsky.social · 05/03/2026

We have a new paper out today from superstar Nora Herzog! A virus that fluidizes the nucleus to enable replication! Check it out here: lnkd.in/e-xV8acK This was an amazing collaboration with Ian Mohr and Angus Wilson

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Liam Holt @liamholt.bsky.social · 21/10/2023

Reposting now we are in double digits! Repost plz :)

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Liam Holt @liamholt.bsky.social · 21/10/2023

Thanks!

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Reposted by Liam Holt

Kim Reynolds @kreynoldslab.bsky.social · 02/10/2023

Come join us! We're looking for not just one, but two postdoctoral fellows. We have one position open in biosynth pathway optimization, and another to examine how E. coli responds to perturbations in essential gene abundance. For details: www.utsouthwestern.edu/research/pos...

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Liam Holt @liamholt.bsky.social · 01/10/2023

6/5 (future questions) Are the physical properties of the cell interior used as information? Can cells use these physical cues to regulate endogenous condensates? Thanks to amazing collaborators: Jon Alberts @ElevyLab Matheus Viana

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Liam Holt @liamholt.bsky.social · 01/10/2023

However, ATP-dependent cellular activities are essential for condensate growth. These activities, especially actomysosin dynamics, work their magic by reducing elastic confinement for mesoscale condensates. 5/5

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Liam Holt @liamholt.bsky.social · 01/10/2023

Our experiments and simulations unveiled that macromolecular crowding has a dule role in condensate formation dynamics: crowding promotes nucleation but inhibits condensate growth. 4/5

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Liam Holt @liamholt.bsky.social · 01/10/2023

To investigate, we developed the synDrops system, an inducible synthetic phase separation system with a well-defined geometry. synDrops enable us to analyze condensate formation kinetics within yeast and mammalian cells and are amenable to simulation. 3/5

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Liam Holt @liamholt.bsky.social · 01/10/2023

The cell interior is a highly complex environment! It’s active, crowded at the mesoscale and exhibits viscoelastic properties. But how does this complex intracellular environment impact phase separation within cells? 2/5

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Liam Holt @liamholt.bsky.social · 01/10/2023

Excited to announce our latest @biorxivpreprint! Mesoscale molecular assembly is favored by the active, crowded cytoplasm Tong Shu led the charge, with @glenhocky and @Gaurav6032 tinyurl.com/2rrkw7r7 Bluetorial! 1/5

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