An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment ...

Schweizer et al. profile the tumor progression from non-invasive serous borderline tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating cell-type resolved Deep Visual Proteomics and spatial transcriptomics, they identify and validate several drivers of transformation as well as a novel combination treatment for this chemo-resistant disease.

Schweizer et al. profile the tumor progression from non-invasive serous borderline tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating cell-type resolved Deep Visual Prot...

Epithelial serous borderline tumors (SBT) are non-invasive neoplastic ovarian lesions that may recur as chemo-resistant low-grade serous cancer (LGSC)…

The fallopian tube undergoes extensive cellular and molecular changes during the menstrual cycle and aging. Here, Weigert et al. present a single-cell atlas of the normal human fallopian tube revealin...