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LCBM

@lcbm-epfl.bsky.social
343 followers 881 following 3 posts

Laboratory of Biophysical Chemistry of Macromolecules (LCBM) headed by @beatfierz.bsky.social at EPFL | Run by LCBM members

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Reposted by LCBM
David Suter @davidsuter.bsky.social · 18/03/2026
How do electrostatic forces impact TF search ? In joint effort with @beatfierz.bsky.social , tour-de-force from @simsakong.bsky.social who single-handedly combined in vitro SPT on DNA & chromatin, in cellulo SPT, ChIP-seq and ATAC-seq www.nature.com/articles/s41...
nature.com
Electrostatic properties of disordered regions control transcription factor search and pioneer activity - Nature Communications
This work describes how positive charge in the peptide chain flanking the DNA-binding domain of transcription factors speeds up their search on free and chromatinized DNA, helping to explain why some ...
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Reposted by LCBM
Sim Sakong @simsakong.bsky.social · 18/03/2026
I’m excited to share that my PhD work is now published in @natcomms.nature.com! Big thanks to @davidsuter.bsky.social & @beatfierz.bsky.social for your guidance throughout this work. We show that electrostatic differences in disordered regions control TF search and chromatin invasion. More details👇
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LCBM @lcbm-epfl.bsky.social · 18/03/2026
TFs search are governed by many parameters, what about electrostatic forces? @simsakong.bsky.social led a multi-scale study on Sox2 revealing how electrostatic interactions influence its search. In close collaboration with @davidsuter.bsky.social. Congratulations Sim 🎉 www.nature.com/articles/s41...
nature.com
Electrostatic properties of disordered regions control transcription factor search and pioneer activity - Nature Communications
This work describes how positive charge in the peptide chain flanking the DNA-binding domain of transcription factors speeds up their search on free and chromatinized DNA, helping to explain why some ...
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Reposted by LCBM
Beat Fierz @beatfierz.bsky.social · 21/05/2025
Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established. www.science.org/doi/10.1126/...
science.org
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
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Reposted by LCBM
Alexandra Teslenko @alexateslenko.bsky.social · 22/05/2025
If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! 🎉📄🧬🔬 Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support! doi.org/10.1126/scia...
doi.org
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
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LCBM @lcbm-epfl.bsky.social · 22/05/2025
Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇 www.science.org/doi/10.1126/...
science.org
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
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LCBM @lcbm-epfl.bsky.social · 22/05/2025
Congratulations @matteodoudin.bsky.social for this PhD fellowship 🥳🎉. Stay tuned for his next achievements about nucleosome depletion.
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Reposted by LCBM
Carlos Moreno-Yruela @carlosmyruela.bsky.social · 04/02/2025
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 www.nature.com/articles/s41... (1/8) #ChemBio #ChemSky
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