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Reposted by Léa Bernaleau

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · 10/02/2025

Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis. Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.

rupress.org

No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis | Journal of Experimental Medicine | Rockefeller University Press

Bernaleau et al. show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the E

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Léa Bernaleau @lbernaleau.bsky.social · 05/02/2025

Thrilled to see our recent paper on CCDC134 highlighted in @jem.org ! Grateful for the opportunity to contribute to this field and engage in meaningful discussions!

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Reposted by Léa Bernaleau

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · 28/01/2025

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSky

wp.unil.ch

Symposium immunobiology

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Reposted by Léa Bernaleau

Broz Lab @brozlab.bsky.social · 28/01/2025

Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press! www.biorxiv.org/content/10.1...

biorxiv.org

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells

NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...

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Léa Bernaleau @lbernaleau.bsky.social · 25/01/2025

I’m thrilled to share our latest work from the @rebsamenlab.bsky.social, now published in @naturecomms.bsky.social! For the first time, we reveal the importance of the SLC15A4-TASL-IRF5 pathway in vivo. It was a great pleasure to contribute to this project!

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Reposted by Léa Bernaleau

Alexis A. Jourdain @jourdainlab.bsky.social · 16/12/2024

📢We're recruiting📢 Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo! Please share #uridine #cancermetabolism #immunometabolism @unil.bsky.social 🔗(PDF): www.jourdainlab.org/wp-content/u...

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Léa Bernaleau @lbernaleau.bsky.social · 10/12/2024

I’m proud to share the latest work of my PhD thesis, just published in @jexpmed.bsky.social! You’ll find how CCDC134 controls TLR biogenesis through the ER-chaperone Gp96, a very exciting discovery! rupress.org/jem/article-... More info here: bsky.app/profile/rebs...

rupress.org

CCDC134 controls TLR biogenesis through the ER chaperone Gp96

A loss-of-function genetic screen identifies the ER-resident protein CCDC134 as an essential regulator of Toll-like receptor (TLR) responses. CCDC134 binds

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