Getting more protein has been all the rage. In sedentary people, that advice could accelerate aging.

Dietary protein is a key regulator of health and longevity across species, and restriction of proteins or other specific amino acids has emerged as a potential strategy to promote healthy aging. Here,...

Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched-chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with...

The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target...

Rapamycin is largely compatible with the physical and skeletal muscle benefits of progressive weighted wheel running (PoWeR). The detrimental effects of rapamycin on glucose metabolism in the context...

Despite the beneficial impact of bariatric surgery on obesity and metabolic disease, continued post-surgical obesity and weight recurrence are common,…

Reducing dietary levels of protein or specific essential amino acids (EAAs) promotes favorable metabolic reprogramming, including improved glucose tolerance, increased insulin sensitivity and reduced ...

In this study, we demonstrated that metabolic responses to a daily-fed caloric restriction (CR) protocol remain robust in mice that cannot engage in canonical ketogenesis. This surprising finding is ...

Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...

Restriction of dietary BCAAs protects male mice from the metabolic consequences of both normal- and high-protein diets. BCAA restriction also protects from hepatic cellular senescence in vivo and in ...

Reducing dietary levels of protein or specific essential amino acids (EAAs) promotes favorable metabolic reprogramming, including improved glucose tolerance, increased insulin sensitivity and reduced ...

In this study, we demonstrated that metabolic responses to a daily-fed caloric restriction (CR) protocol remain robust in mice that cannot engage in canonical ketogenesis. This surprising finding is ....