iiinova — where your digital self keeps evolving

Ken Youens-Clark @kyclark.bsky.social · 18/09/2026

I just got a bug report on one of my public repos that ended with a suggestion that I pay the contributor $5 to thank them.

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Ken Youens-Clark @kyclark.bsky.social · 25/08/2026

Me with a new petard: Heck yeah this is awesome! Me getting hoisted: OH NOES

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Ken Youens-Clark @kyclark.bsky.social · 25/08/2026

My parents ran an advertising agency when I was a kid. They went to Nashville to cut some jingles in the 70s, and Dolly Parton walked into the studio kitchen while my mom was getting coffee. Dolly introduced herself like she wasn't already known to millions. The woman was genuinely sweet and kind.

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Reposted by Ken Youens-Clark

MDRepo @mdrepo.bsky.social · 12/08/2026

Status update for mdrepo.org We've ingested the mdCATH dataset: 26,990 replicate sets (5,398 CATH domains, each at 5 temps). A couple examples: mdrepo.org/explore/MDR0... mdrepo.org/explore/MDR0... We now provide easy access to data from mdCATH, MISATO, ATLAS, and GPCRmd; more coming soon.

mdrepo.org

MDRepo

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Ken Youens-Clark @kyclark.bsky.social · 31/07/2026

The daughter of Ming the Merciless made 8-year-old me realize I wanted a baddie.

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Ken Youens-Clark @kyclark.bsky.social · 24/07/2026

I miss that kid who pet the dogs.

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Ken Youens-Clark @kyclark.bsky.social · 02/07/2026

How I imagine Chicago Pope deciding to excommunicate SSPX.

Jake and Elwood Blues sitting in The Bluesmobile when Jack says "I hate Illinois Nazis" just before Elwood tries to run over said Illinois Nazis with said Bluesmobile.

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Ken Youens-Clark @kyclark.bsky.social · 25/06/2026

I get to work with these fine folks @wheelerlab.org and this is Big News!

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Ken Youens-Clark @kyclark.bsky.social · 19/05/2026

Another crucial bit of context here is that Edmund Pettus was an officer in the CSA and a Grand Dragon of the KKK, and they have never changed the name of this bridge. I had to live Jackson, MS, next to the Ross Barnett Reservoir, named for another horrid racist.

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Ken Youens-Clark @kyclark.bsky.social · 18/05/2026

I wrote an Eagle's cover about how my AI girlfriend doesn't work. It's called "Glitchy Woman."

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Ken Youens-Clark @kyclark.bsky.social · 18/05/2026

I've created py4bfx.com to host all the free YouTube videos I've made for my book Mastering Python for Bioinformatics (O'Reilly, 2022). This material will be used by the NCSU Bioinformatics Research Center for an upcoming introduction to programming for biology. #python #bioinformatics #programming

py4bfx.com

Mastering Python for Bioinformatics

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Ken Youens-Clark @kyclark.bsky.social · 14/05/2026

If Mark Ruffalo ate too much, he'd be called Mark Stuffalo.

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Ken Youens-Clark @kyclark.bsky.social · 05/05/2026

I get it. I once fell in love with spellcheck.

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Ken Youens-Clark @kyclark.bsky.social · 04/05/2026

"I ain't nothing but tired" I hear you, Boss.

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Ken Youens-Clark @kyclark.bsky.social · 24/04/2026

When my wife says "I moved that thing that was in the way" she means "I put it in the already crowded garage where you store too many bicycles, and I probably put it on your workbench that is barely visible under all your half-abandoned projects."

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Ken Youens-Clark @kyclark.bsky.social · 20/04/2026

Almost to 2K subscribers on my YouTube channel www.youtube.com/@kyclark

An image titled "Channel analytics" showing the current number of subscribers at 1999 with an increase of 16 in the last 28 days.

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Ken Youens-Clark @kyclark.bsky.social · 10/04/2026

I don't want to brag, but the dentist says I'm a big salivator.

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Ken Youens-Clark @kyclark.bsky.social · 07/04/2026

I’m judging people who use Times New Roman on their phone lock screen.

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Ken Youens-Clark @kyclark.bsky.social · 11/03/2026

1990: I, an 18-year-old male, watch the US invade the Middle East and fear that I'll be drafted to fight. 2026: I, a 53-year-old, watch the US invade the Middle East and fear that my 18-year-old son will be drafted to fight.

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Ken Youens-Clark @kyclark.bsky.social · 20/02/2026

Has anyone checked the tariff shelf this morning?

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Reposted by Ken Youens-Clark

Travis Wheeler @wheelerlab.org · 05/02/2026

Please spread the word: We invite applications to a two-week Computational Biology workshop in Singapore, June 14-27. This NSF-funded workshop brings together 16-20 US grad students with international peers. Apply by March 21: compbioasia.net 🧵 Details below:

compbioasia.net

Compbio Asia

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Ken Youens-Clark @kyclark.bsky.social · 20/01/2026

I've been thinking about making friends with a neighborhood corvid. Maybe hold out some peanuts in my hand and see what happens.

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Ken Youens-Clark @kyclark.bsky.social · 25/11/2025

Looking at used bicycles on Craigslist just to feel something.

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Ken Youens-Clark @kyclark.bsky.social · 03/11/2025

Shout out to Fishbone, who was singing to my white-college-boy ass back in the early 90s about fascism. Not something I ever thought about growing up, and they were trying to get me to see it.

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Ken Youens-Clark @kyclark.bsky.social · 20/10/2025

My ride share car smells like air freshener and pot. Reminds me of the summer I lived in a house with six band mates and there was a cinnamon air freshener in the bathroom and the keyboard player came out and said “Mmm cinnamon dump!

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Ken Youens-Clark @kyclark.bsky.social · 26/09/2025

I've release a new user interface for mdrepo.org, an open repository of molecular dynamic simulations for proteins, written in Elm (specifically Elm Land). The original version used React/JS and was slow and failed with exceptions. The Elm version should have zero runtime exceptions. #elm-lang

mdrepo.org

MDRepo

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Ken Youens-Clark @kyclark.bsky.social · 28/08/2025

Tried to call my step-dad and got his voice mail with the message recorded by my mom, who died in June.

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Ken Youens-Clark @kyclark.bsky.social · 28/08/2025

A friend shared a lovely Dijkstra essay. It's short enough to read in a few minutes, and is damning of the current attempt to replace our brains with AI generated writing and vibe coding. www.cs.utexas.edu/~EWD/transcr...

cs.utexas.edu

E.W.Dijkstra Archive: On the foolishness of "natural language programming". (EWD 667)

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Ken Youens-Clark @kyclark.bsky.social · 27/08/2025

I've become increasingly disappointed my publisher, @oreilly.bsky.social, leaning so heavily into vibe coding. They canceled my Rust course in which I attempt to methodically teach how to learn Rust by writing it oneself. They fired the really good acquisition editors who brought me on board.

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Ken Youens-Clark @kyclark.bsky.social · 26/08/2025

A friend would ride with his mom to drop his sister off for piano lessons. Every time, his mom asked him if he'd like to take lessons, too. Every time, he said no. One day, he decided he would say yes the next time his mom asked. She never did, and he never studied the piano.

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Ken Youens-Clark @kyclark.bsky.social · 22/08/2025

I don't understand the government taking 10% of Intel profits. Like, isn't that what taxes are supposed to be?

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Ken Youens-Clark @kyclark.bsky.social · 20/08/2025

My one food service experience was 27 years ago at a Cracker Barrel in Lewisville, TX, my last semester in college after my folks kicked me off the payroll after a huge fight over my girlfriend.

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Ken Youens-Clark @kyclark.bsky.social · 21/07/2025

I like Weird Al but not weird AI and this is a very confusing time for me.

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Ken Youens-Clark @kyclark.bsky.social · 18/06/2025

My retirement plan is somewhere between outfitting a Tuff Shed or cliff-diving a la Midsommar with the backup head hammer.

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Ken Youens-Clark @kyclark.bsky.social · 02/06/2025

My current project is continued support and development on this. It's really cool.

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Reposted by Ken Youens-Clark

Lupita Nihongo @otsumamiboy.blacksky.app · 31/05/2025

Trying to reconcile how all positive change had to be incremental, studied in perpetuity & ultimately stalled with ‘how are we gonna pay for that?’ but dismantling everything was done quickly, ham-fistedly & with total disregard for cost of money and lives & no institutional guardrails mattered.

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Ken Youens-Clark @kyclark.bsky.social · 06/05/2025

My job at the Univ. of Arizona has been funded by the NSF and NIH. The money runs out pretty soon, so I’m seeking a new role. #Python #Rust #Elm #Bioinformatics

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Ken Youens-Clark @kyclark.bsky.social · 24/04/2025

My first book, Tiny #Python Projects (Manning, @manningbooks.bsky.social, 2020), has been translated into #Russian.

A Russian translation of the book, Tiny Python Projects, by Ken Youens-Clark. The cover is vertically divided into a black left side and white right side and features a woman from the 1805 edition of Sylvain Marechal's four-volume compendium of regional dress customs. The woman is dressed in a long green dress with long sleeves and buttons up the front. She is wearing a salmon-colored headdress over a tall hat. The toes of her right foot peak from under the dress.

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Ken Youens-Clark @kyclark.bsky.social · 24/03/2025

I found the #Rust game engine #Macroquad very easy to use in making this little animation of bouncing balls.

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Ken Youens-Clark @kyclark.bsky.social · 14/03/2025

Can't stress-eat if I don't start stress-baking.

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Ken Youens-Clark @kyclark.bsky.social · 10/03/2025

Her: I don't like these pants. They're too big. What do you think? Me thinking "This is a trap. Don't answer." Her: I should probably change. What do you think? Me: I agree. They're too big and you should change. Her: I can't believe you don't like my pants.

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Ken Youens-Clark @kyclark.bsky.social · 28/02/2025

I'm releasing a fun little #Rust tool called "readr" that will print file/STDIN to the screen slow enough to read, kind of like how computers all seem to work in the movies. FWIW, I was exploring async programming with tokio. crates.io/crates/readr

crates.io

crates.io: Rust Package Registry

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Ken Youens-Clark @kyclark.bsky.social · 28/02/2025

I usually talk about my work in #Rust, but I've also done a lot with #Python. The GitHub repo for my first book, Tiny Python Projects (Manning, 2020), has now hit 2.5K forks! You can find all the videos on YouTube. github.com/kyclark/tiny...

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Ken Youens-Clark @kyclark.bsky.social · 27/02/2025

I've always thought "Hot Water Burn Baby" would make a great band name.

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Ken Youens-Clark @kyclark.bsky.social · 04/02/2025

Does anybody in #bioinformatics need a #Rust program to convert Stockholm format into FASTA? I'm using this to split multiple sequence alignments in an STK file into separate FASTA files. github.com/TravisWheele...

github.com

GitHub - TravisWheelerLab/stk2fasta: Split Stockholm file into FASTA files

Split Stockholm file into FASTA files. Contribute to TravisWheelerLab/stk2fasta development by creating an account on GitHub.

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Ken Youens-Clark @kyclark.bsky.social · 31/01/2025

Here's the link to my @oreilly.bsky.social #Rust course on Monday. If you are a university student, it's very likely that school's library has a subscription to the O'Reilly Learning platform, so it's free to dip in! learning.oreilly.com/live-events/...

learning.oreilly.com

Basic Rust Programming

Kickstart your Rust journey with Command-Line Programs

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Ken Youens-Clark @kyclark.bsky.social · 29/01/2025

The 0.7 version of our #bioinformatics #Rust crate Sufr for parallel creation/querying of suffix arrays includes a deeper test suite that found many bugs I fixed. crates.io/crates/sufr

crates.io

crates.io: Rust Package Registry

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Ken Youens-Clark @kyclark.bsky.social · 27/01/2025

If this dune's Arrakeen, Don't come a-knockin'.

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Ken Youens-Clark @kyclark.bsky.social · 07/01/2025

I've pushed a new version of Sufr, a #Rust implementation for fast parallel creation and searching of a suffix array. This release includes support for spaced seeds and searches requiring almost no RAM. crates.io/crates/sufr

crates.io

crates.io: Rust Package Registry

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