Reposted by Kurt Thornhikikomorphism @hikikomorphism.bsky.social · 12/10/2026trying something: if you make a reasonably-sized donation to a trans charity of your choice, I'll run this against the repo of your choice. I'm currently at over 100 correctness bugs found last week across Apollo Router, OAI Codex, uv, Prometheus, Babel, jj, and rv, with ten fixes already merged. 49222
Reposted by Kurt ThornSkynetAndChill.com @druce.ai · 11/10/2026Cockroach Labs' hospital-style team of coding agents built IBM Db2 migration support in under two days for $4,172; Oracle support took nine monthscockroachlabs.comFive months treating bugs like patients and coding agents like a medical teamHow Cockroach Labs built MOLT Sinai, an AI coding “teaching hospital” that shipped IBM Db2 migration support in under two days. 021
Reposted by Kurt ThornTed Underwood @tedunderwood.com · 11/10/2026AI is doing such a good job of disaggregating abstractions we assumed were fundamental (writing, intelligence, &c) that I don't know why this isn't everyone's default assumption 711614
Reposted by Kurt Thornbryan newbold @bnewbold.net · 07/10/2026ah damn, RIP Margaret Hamilton. she took safety-critical software engineering seriously, and got people to the moon and back. news.mit.edu/2026/margare... 102144084734
Reposted by Kurt ThornSean O’Kane @okane.fyi · 07/10/2026SpaceX is basically daring lenders to pony up $40 billion so it can buy Nvidia chips on what sounds like a cocktail napkin www.ft.com/content/d3f5... 1724862
Kurt Thorn @kurtthorn.bsky.social · 06/10/2026Can attest, this is very effective at finding bugs and opening fixes 061
Kurt Thorn @kurtthorn.bsky.social · 05/10/2026Yes, for making slides I now have an agent write svg. I use genAI for making small images or icons that are part of those slides, but having the full slide be svg makes it reproducible and easy to modify. 030
Kurt Thorn @kurtthorn.bsky.social · 04/10/2026Very cool! I’m curious what tools you used to make it. 100
Kurt Thorn @kurtthorn.bsky.social · 04/10/2026I’m having my agents design a cosplay Sauron costume for my son, and Opus is noticeably better at making patterns and designed than Sol 6.1 011
Kurt Thorn @kurtthorn.bsky.social · 04/10/2026I agree with this. It’s one of the first things I added to my work agent after it got stuck in a loop and burned $1500 overnight 100
Reposted by Kurt Thornconputer dipshit @davidcrespo.bsky.social · 03/10/2026a lot of what I do is “I know there is a way to do this, and I can picture a few, list them and help me pick the best one. here’s the one I like, what are the downsides” 4594
Kurt Thorn @kurtthorn.bsky.social · 02/10/2026Honestly these days I would just ask a coding agent to build a website and set you up to host it on any of many locations. Eg thornlab.dev is minethornlab.devKurt Thorn, Ph.D.CTO and AI/ML leader in drug discovery. San Francisco, CA. 120
Reposted by Kurt ThornSam @samd.bsky.social · 27/09/2026we could solve the western water crisis overnight by simply charging alfalfa farmers market rates for water 211004180
Kurt Thorn @kurtthorn.bsky.social · 26/09/2026I’ve also built a bunch of specialized hobby projects - a structured cocktail database; a UK canal boar routing app; a fantasy weapon creator. 020
Kurt Thorn @kurtthorn.bsky.social · 26/09/2026This. I’ve realized that at work I’m solo reimplementing the functions of commercial software that sells for like 90k/user/year, and it’s customized to solve exactly my problems, exactly how I want. 240
Reposted by Kurt ThornBen Collins @bencollins.bsky.social · 26/09/2026This is extraordinarily well written. 832811443
Kurt Thorn @kurtthorn.bsky.social · 25/09/2026I think it did it using the Pi CLI but I run them through paseo which has its own tools for one agent to invoke another. I didn’t worry about the details, I just told it to do it. 010
Reposted by Kurt ThornEthan Mollick @emollick.bsky.social · 25/09/2026"Hey Opus, I want you to make a Zine by Claude, expressing something fundamental about Claudishness or your perspective. Think the original 2600, Principia Discordia, punk zines, etc...." Not bad. I appreciate it mocking my prompt & itself. Full thing: stateless-zine.netlify.app 101039
Kurt Thorn @kurtthorn.bsky.social · 25/09/2026I’ve been getting opus 5.5 to hand off routine work to Luna 6 to save tokens and so far it seems good. Opus was impressed with Luna 6 🤷 140
Kurt Thorn @kurtthorn.bsky.social · 25/09/2026Sequencing.com is a little cheaper. Been thinking about doing this myself.sequencing.comSequencing | Test 100% Of Your Genes | DNA Kits + ReportsEverything you need to transform your DNA into clear solutions for better health. Whole genome sequencing (WGS) kits + DNA Reports + Privacy Forever protection. 000
Kurt Thorn @kurtthorn.bsky.social · 25/09/2026Yes, I was a judge for the video version a number of years back and it was a pretty informal process. 010
Reposted by Kurt ThornAgonyFlips @agonyflips.bsky.social · 20/09/2026When you're ticked off and a friend sends you something to make you feel better. 🐑🔊 498158273860
Kurt Thorn @kurtthorn.bsky.social · 21/09/2026Agree. My hobby project is building a cocktail database (mixology.tools) and I recently wanted to compute ABV for every cocktail. Astra had no problem delegating Luna subagents to look up alcohol content for all the ingredients.mixology.toolsMixology Tools — Cocktail Recipe DatabaseOpen cocktail database with hierarchical ingredient taxonomy and free public API 120
Reposted by Kurt ThornMatt Hodges @matthodges.bsky.social · 20/09/2026I think a lot of it is not so much a knowledge gap of what AI can do but more a knowledge gap of what computers can do. 1203
Kurt Thorn @kurtthorn.bsky.social · 21/09/2026I’ve started using paseo+tailscale to do this in a model / harness-agnostic way. It works well. 000
Kurt Thorn @kurtthorn.bsky.social · 20/09/2026This discussion, and many of the similar ones going on, make me feel like we should require everyone take a philosophy course or two. There’s a certain intellectual humility in learning by how hard it is to formalize and prove seemingly simple ideas. 070
Kurt Thorn @kurtthorn.bsky.social · 20/09/2026I strongly suspect that wet lab is for making small molecule drugs based on some of their job postings - so I don’t think it will be doing a lot of biology engineering. 070
Kurt Thorn @kurtthorn.bsky.social · 20/09/2026I recently read Artifact Space and its sequel which might hit your sweet spot. Also the Vatta’s War series was pretty good. 120
Reposted by Kurt ThornSkynetAndChill.com @druce.ai · 19/09/2026Astra comicsreddit.comFrom the ChatGPT community on Reddit: Astra Creates Great ComicsExplore this post and more from the ChatGPT community 011
Kurt Thorn @kurtthorn.bsky.social · 17/09/2026Does asking for an ontology perform v better than just asking for an architecture design? 010
Kurt Thorn @kurtthorn.bsky.social · 17/09/2026I can’t see this without thinking of Scott’s doomed Antarctic expedition 010
Kurt Thorn @kurtthorn.bsky.social · 17/09/2026So I asked it to re-refine the structure with both ligands - it did so, and then confirmed that the X-ray data can’t distinguish between them. This took a morning, in parallel with other work. AI not only lets you move faster, it lets you do things you would never have time to do otherwise. 020
Kurt Thorn @kurtthorn.bsky.social · 17/09/2026I recently was ingesting some data from the SI section of a paper, which reported, among other things, biochemical data for a ligand from a pdb structure. Without prompting, my agent found out that the pdb ligand structure differed from the SI ligand structure. 120
Reposted by Kurt Thornbrennan @brennan.computer · 17/09/2026oh man I wish, I WISH, I could show 20 year old me everything I do now it would be the coolest thing in the whole world, his eyes would be so wide and shining. he'd die to live here with me every piece of every technology we liked and worked with then is just so so so good now 3583
Kurt Thorn @kurtthorn.bsky.social · 17/09/2026While building ML models, I had an agent discover a data entry error in ChEMBL by comparison to the original paper. I didn’t ask it to look for errors, it just found this in the course of its work. 000
Kurt Thorn @kurtthorn.bsky.social · 16/09/2026I use paseo + tailscale for this with any cli agent. It’s great. 010
Kurt Thorn @kurtthorn.bsky.social · 13/09/2026Appropriately, my son watched the veritasium video that features this and the LTEE last night and I got to say “I know the people who did that”! 010
Reposted by Kurt ThornMax Woolf @minimaxir.bsky.social · 12/09/2026finally, good clickbait eddie.codes/posts/pandas...eddie.codesPandas Should Go ExtinctPandas has taken us a long way, but it's time for a new bear 4434
Reposted by Kurt Thornmr. TIM @timkellogg.me · 12/09/2026if you're having trouble with Astra, it's probably old skills. Point your agent at these two URLs and use them to upgrade skills: 1. developers.openai.com/blog/rethink... 2. github.com/openai/codex...developers.openai.comRethinking skills and prompts for GPT-6 Astra | OpenAI DevelopersRevisit skill descriptions, AGENTS.md, and task prompts to avoid bloated context. 7783
Kurt Thorn @kurtthorn.bsky.social · 11/09/2026The problem for both companies is that they don’t have much lock-in - model switching costs are low. 030