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Kristiina Kanerva

@kkanerva.bsky.social
10 followers 13 following 1 posts

PhD • University Researcher in Elina Ikonen lab @helsinki.fi I ❤️🔬 interested in lipid trafficking, microscopy and cell biology of cholesterol

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Kristiina Kanerva @kkanerva.bsky.social · 10/11/2025
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex | Science www.science.org/doi/10.1126/...
science.org
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...
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Reposted by Kristiina Kanerva
Science Magazine @science.org · 06/11/2025
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more this week: scim.ag/4nFEGO7
Lipid droplet growth is orchestrated by the seipin complex, which provides a structural platform for droplet nucleation and expansion. The microprotein adipogenin fine-tunes seipin’s conformation, remodeling its architecture to regulate lipid storage capacity. This modulation results in the formation of fewer but larger lipid droplets, revealing a key mechanism in lipid homeostasis.
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