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Kira Poskanzer

@kiraposkanzer.bsky.social
637 followers 555 following 41 posts

Venture Science @Astera. Translational science @ArcadiaScience. Associate Professor @UCSF. Astrocytes and neurons.

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Reposted by Kira Poskanzer
The Transmitter @thetransmitter.bsky.social · 24/03/2026
“Based on astrocytic activity alone, you can tell whether a mouse is in its comfort zone,” a new study suggests. By Holly Barker www.thetransmitter.org/spectrum/ast...
thetransmitter.org
Astrocytes in mouse amygdala encode emotional state
The glial cells’ activity reliably tracks with freezing, hesitancy and other behaviors reminiscent of anxiety.
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Kira Poskanzer @kiraposkanzer.bsky.social · 06/10/2025
Thanks to @ashleyingiosi.bsky.social for this thoughtful primer about our recent astrocyte/sleep paper!
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Reposted by Kira Poskanzer
Maxine 💃🏼 @maxine.science · 04/10/2025
🧠📈 Evidence is mounting for all the ways the astrocyte network—that “second brain” woven between neurons—integrates modulatory signals to shape neural dynamics & brain state. It was awesome to collab on this investigation on the intricate interplay between histamine and other signals in astrocytes!
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Reposted by Kira Poskanzer
PLOS Biology @plosbiology.org · 03/10/2025
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap
Top: Example confocal micrograph showing astrocyte expression of S100β (green), Cre-RFP (magenta), and H1R mRNA (cyan). Left: summed z-projection of all three confocal channels. Middle: RNAscope detected H1R mRNA with white and yellow arrows indicating example WT (S100β+/RFP−/H1R+) and cKO (RFP+/H1R−) soma regions of interest (ROIs), respectively. Right: Cre-RFP expression (top, magenta) and S100β expression (bottom, green). Scale bars = 10 μm. Bottom: Example confocal micrograph showing astrocytic Cre-RFP (magenta), neuronal NeuN (green), and nuclear marker DAPI (blue). Left: summed z-projection of all three confocal channels. Middle: astrocytic Cre-RFP signal with astrocyte soma ROIs overlaid. Right: NeuN signal with astrocyte soma ROIs overlaid. Scale bars = 50 μm.
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Reposted by Kira Poskanzer
Vincent Tse @vincenttse.bsky.social · 02/10/2025
Really excited to see this work from my postgrad days come out of its "slumber" 💤 If you are interested in how astrocytes interact with neuromodulatory systems to regulate cortical states, this is for you!
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Kira Poskanzer @kiraposkanzer.bsky.social · 02/10/2025
Congrats to Charlotte Taylor and team for dissecting how astrocyte networks integrate histamine to modulate adenosine over sleep and wake in unexpected ways: dx.plos.org/10.1371/jour... @vincenttse.bsky.social @maxine.science @trishavv.bsky.social
dx.plos.org
Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake
While histamine-1-receptor (H1R) signaling in neurons regulates arousal, these receptors are also abundant on cortical astrocytes. This study shows that astrocytic H1R signaling modulates calcium acti...
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Kira Poskanzer @kiraposkanzer.bsky.social · 24/07/2025
Brainbow
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Kira Poskanzer @kiraposkanzer.bsky.social · 08/07/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 08/07/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 26/06/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 14/06/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 11/06/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 09/06/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 04/06/2025
Fashion show outfit that looks like a Neuropixels probePictures of Neuropixels probes
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Kira Poskanzer @kiraposkanzer.bsky.social · 09/04/2025
Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals: Cell www.cell.com/cell/fulltex...
cell.com
Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals
AQuA2 is a powerful data analysis platform that decomposes time-lapse imaging datasets into elementary signaling events, allowing for accurate quantification of spatiotemporal molecular activity patte...
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Kira Poskanzer @kiraposkanzer.bsky.social · 10/03/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 09/03/2025
Watch the videos
nytimes.com
It’s Hard to Believe How Cool These Dresses Are
Illuminated, kaleidoscopic dresses at Anrealage made the case that we’re all walking billboards.
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Kira Poskanzer @kiraposkanzer.bsky.social · 06/03/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 04/03/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 28/02/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 27/02/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 25/02/2025
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Kira Poskanzer @kiraposkanzer.bsky.social · 07/02/2025
Unexpected glia reference alert!
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Kira Poskanzer @kiraposkanzer.bsky.social · 05/02/2025
Capacitance compensation
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Kira Poskanzer @kiraposkanzer.bsky.social · 27/01/2025
Lipid droplets
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Kira Poskanzer @kiraposkanzer.bsky.social · 26/01/2025
YFP
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Kira Poskanzer @kiraposkanzer.bsky.social · 16/12/2024
Marin mushrooms
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Kira Poskanzer @kiraposkanzer.bsky.social · 08/12/2024
My what
Image reads: 
Trends, Now serving: mood-brightening ideas for your dopamine menu
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Kira Poskanzer @kiraposkanzer.bsky.social · 22/11/2024
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Kira Poskanzer @kiraposkanzer.bsky.social · 18/11/2024
Ultrastructure
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Reposted by Kira Poskanzer
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 17/11/2023
A Photoactivatable Norepinephrine for Probing Adrenergic Neural Circuits www.biorxiv.org/content/10.1101/202…
biorxiv.org
A Photoactivatable Norepinephrine for Probing Adrenergic Neural Circuits https://www.biorxiv.org/content/10.1101/2023.11.13.566764v1
Norepinephrine (NE) is a critical neuromodulator that mediates a wide range of behavior and neurophy
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Kira Poskanzer @kiraposkanzer.bsky.social · 29/09/2023
SF moon
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Kira Poskanzer @kiraposkanzer.bsky.social · 22/09/2023
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Kira Poskanzer @kiraposkanzer.bsky.social · 11/09/2023
Ocular dominance columns
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Kira Poskanzer @kiraposkanzer.bsky.social · 08/09/2023
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Kira Poskanzer @kiraposkanzer.bsky.social · 04/09/2023
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Kira Poskanzer @kiraposkanzer.bsky.social · 25/08/2023
Check out a recent @arcadiascience.bsky.social project looking for viruses in human brains 🧠: research.arcadiascience.com/pub/res…
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