Sign in

kiki 🏳️‍⚧️🏳️‍🌈🧬

@kiki-omics.bsky.social
22 followers 43 following 7 posts

she/they 🏳️‍⚧️ All things cell-free DNA 🧬 Lecturer in Human Genetics at @exeter.ac.uk | Previously at @ox.ac.uk & @sangerinstitute.bsky.social experts.exeter.ac.uk/45188-kiki-can…

PostsRepliesMedia
kiki 🏳️‍⚧️🏳️‍🌈🧬 @kiki-omics.bsky.social · 23/06/2026
Our review on the role of cfDNA in lupus is out today in Frontiers in Immunology @frontiersin.bsky.social 🎉 Huge congrats to Emily Jones, a very talented MSc Genomic Medicine student at @exeter.ac.uk who led this work. It was an absolute pleasure working with her 🌸 Full text at: bit.ly/4uRy5DU
Infographic comparing epigenomic and fragmentomic features in cell-free DNA research. The left panel shows DNA hydroxymethylation, methylation, and histone marks, with associated icons. The right panel highlights antibody binding, fragment sizes, 5’ jagged ends, and 5’ end motifs. Central illustration depicts a healthcare professional drawing blood from a patient. Key findings, such as increased 5hmC, hypomethylation, short fragments enrichment, and reduction in 5’CC motifs, are noted in red text with reference numbers.
030
kiki 🏳️‍⚧️🏳️‍🌈🧬 @kiki-omics.bsky.social · 02/09/2025
🎓 Fully funded PhD at University of Exeter & University of Bath! Work on lupus research using genomics, liquid biopsies & AI. Open to UK + international students. 📧 If interested, please reach out to me by email 📅 Apply by Oct 20 👉 gw4biomed.ac.uk #PhD #Genomics #AI #Bioinformatics
gw4biomed.ac.uk
GW4 BioMed MRC DTP - GW4 BioMed MRC DTP
The GW4 BioMed MRC Doctoral Training Partnership is a collaboration between Bath, Bristol, Cardiff and Exeter Universities.
030
kiki 🏳️‍⚧️🏳️‍🌈🧬 @kiki-omics.bsky.social · 12/08/2025
A lovely editorial on our most recent study, which shows a build-up of DNA in the circulation of patients with severe infections ❤️ www.ndm.ox.ac.uk/news/study-r... You can also find the full study at: bit.ly/4oEv6wP
ndm.ox.ac.uk
Study reveals liver problems may drive DNA build-up in sepsis patients
Researchers at NDM’s Centre for Human Genetics have discovered that cell-free DNA builds up in the blood of patients with sepsis because of impaired liver clearance. These findings show that investiga...
010
kiki 🏳️‍⚧️🏳️‍🌈🧬 @kiki-omics.bsky.social · 12/08/2025
Our study on cfDNA & sepsis is now out in Cell Genomics @cellpress.bsky.social 🥳💙 We measure cfDNA features using NGS and show that cfDNA accumulates in the blood during sepsis, likely because the liver cannot properly clear it. This study was led by @ndm.ox.ac.uk Available at: bit.ly/4oEv6wP
A diagram illustrating the findings of our study. It depicts a person in intensive care, and a vial of blood from which DNA was obtained. Several arrows then indicate which features of this DNA were measured: methylation, fragmentation, nucleosome signatures, and pathogen DNA. Finally, the bottom of the image shows the life cycle of cfDNA, and how our findings point to an accumulation of cfDNA in the plasma, accompanied by an impairment in how the liver clears this DNA.
120
Reposted by kiki 🏳️‍⚧️🏳️‍🌈🧬
Nature @nature.com · 21/05/2025
Nature research paper: Clonal tracing with somatic epimutations reveals dynamics of blood ageing go.nature.com/43NOe1R
go.nature.com
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.
0327
kiki 🏳️‍⚧️🏳️‍🌈🧬 @kiki-omics.bsky.social · 21/02/2025
Super excited to introduce our new study, now available as a preprint: tinyurl.com/2hv97yb4 We profiled circulating cell-free DNA during sepsis to understand why it increases >40-fold during disease. We assess cfDNA methylomes, fragmentomes, and nucleosome footprints. (1/3)
A graphical representation of our experimental design. At the top, we see an illustration of a group of people (31 sepsis cases and 7 controls), from whom blood samples are being taken and cell-free DNA isolated. This DNA is then chemically treated to profile all methylated CpG sites. Finally, the diagram shows how this sequencing data is used to derive information on not only DNA methylation, but also cfDNA fragmentation, and nucleosome positioning.
152
Reposted by kiki 🏳️‍⚧️🏳️‍🌈🧬
bioRxivpreprint @biorxivpreprint.bsky.social · 21/02/2025
The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance www.biorxiv.org/content/10.1101/202…
012
Reposted by kiki 🏳️‍⚧️🏳️‍🌈🧬
Nature Portfolio @natureportfolio.nature.com · 15/02/2025
A Review in Nature Reviews Genetics examines computational and statistical challenges that must be addressed for the rigorous construction of interpretable epigenetic clocks at cell-type and single-cell resolution. go.nature.com/3EKFgt0 🔒
This is figure 1, which shows the biological age and epigenetic clocks.
0336
Reposted by kiki 🏳️‍⚧️🏳️‍🌈🧬
Nuffield Department of Medicine @ndm.ox.ac.uk · 11/02/2025
Today is the #InternationalDayOfWomenAndGirlsInScience! So to celebrate, we'd like to share the words of three inspiring #WomenInScience here at NDM. Discover the advice they'd give to themselves when they started their career in STEM 👩‍🔬🧪🥼
088