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kh-r-rustamov.bsky.social

@kh-r-rustamov.bsky.social
10 followers 27 following 2 posts
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Martin Pacesa @martinpacesa.bsky.social · 28/04/2026
Extremely excited about the results of @adaptyv.bio RBX1 binder design competition! 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕2 performed very well, with 3 out of 7 designs binding to the disordered tail. Overall, only 9 binders worked out of 322 tested, 2.8% hit rate! Proud of the BC2 team ♥️ (Erik, Liza, Leo)
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kh-r-rustamov.bsky.social @kh-r-rustamov.bsky.social · 28/04/2026
We’ve got a binder in the GEM-Adaptyv RBX1 Binder Design Challenge, and it ranked #8 out of 322 tested proteins with a Kd of 570 nM. Congratulations to all the winners, and thanks to the organizers.
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Reposted by @kh-r-rustamov.bsky.social
AI x Bio Discovery @aixbiobot.bsky.social · 06/07/2025
Fold-Conditioned De Novo Binder Design via AlphaFold2-Multimer Hallucination. [new] FoldCraft: uses AlphaFold2-Multimer with contact map loss to hallucinate novel binders with user-defined folds, improving nanobody design.
Figure 1Figure 2Figure 3Figure 4
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Reposted by @kh-r-rustamov.bsky.social
bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 06/07/2025
Fold-Conditioned De Novo Binder Design via AlphaFold2-Multimer Hallucination. www.biorxiv.org/content/10.1101/202…
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Reposted by @kh-r-rustamov.bsky.social
Bioinformatics Advances @bioinfoadv.bsky.social · 23/12/2024
🧬 "MSA clustering enhances AF-Multimer's ability to predict conformational landscapes of protein-protein interactions" explores how MSA sampling improves #AlphaFold's performance in predicting binding mechanisms for proteins with multiple states. Learn more: doi.org/10.1093/bioa... #ProteinFolding
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