iiinova — where your digital self keeps evolving

Keying ZHU

@keyinglia.bsky.social

Microglia~Myelin Postdoc @UCSF (San Francisco) PhD @Karolinska Institutet (Stockholm) MSc @Fudan University (Shanghai) Swedish Research Council (Vetenskapsrådet) Fellow

Posts Replies Media

Reposted by Keying ZHU

European Microglia Webinar Series @microgliaseries.bsky.social · 08/01/2026

Happy new year everyone 🍾 To start the year we have a new webinar coming soon! Prof. Bo Peng from the Institute for Translational Brain Research in China will be our next speaker on January 13th. Check all the information in the flyer and add it to your calendar! 🧬🧠

034

Reposted by Keying ZHU

Harald Lund @haraldlund.bsky.social · 02/01/2026

This paper represents a massive undertaking (6+ years!) led by then PhD student, now Postdoc Keying @keyinglia.bsky.social in collaboration with the Bob Harris lab and many amazing contributors. Thanks to everyone involved! 🧵3/3

022

Reposted by Keying ZHU

Harald Lund @haraldlund.bsky.social · 02/01/2026

Short summary -Aging causes region-specific myelin degeneration in the spinal cord -Microglia activate a protective TGFβ1 autocrine loop -Disrupting microglial Tgfb1/Tgfbr2 leads to myelin loss and behavioral deficits that worsen with age 🧵2/3

121

Reposted by Keying ZHU

Harald Lund @haraldlund.bsky.social · 02/01/2026

Microglia checkpoints promote healthy myelin aging Our new paper is out in Nature Neuroscience @natneuro.nature.com www.nature.com/articles/s41... 🧵1/3

nature.com

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience

Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.

1148