TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.

Mutations get the virus ready to jump

The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...

Vaccines and monoclonal antibodies targeting the respiratory syncytial virus (RSV) fusion protein (F) have recently begun to be widely used to protect infants and high-risk adults. Some other viral pr...

H5N1 is an avian influenza virus that causes respiratory disease in birds and several land and sea mammals. The recent outbreak in the United States, …

Antibodies capable of neutralizing many strains of HIV are being explored as prophylactic and therapeutic agents, but viral escape mutations pose a major challenge. Efforts have been made to experimen...

In the midst of pandemic upheaval, researchers have gained fundamental insights about how the body fends off infections.

When, where and how the H5N1 bird flu virus may evolve and its capacity to spark a pandemic is hard to predict — in part, some researchers say, because of federal restrictions on gain-of-function rese...

Study offers insights into cell death regulation by viruses like SARS-CoV-2, and how bats and humans respond differently to tricks that such viruses use to manipulate the host’s defense

Past influenza pandemics contained polymerase genes from avian influenza viruses, affecting viral replication and pathogenicity.

RHIM is a protein motif facilitating the assembly of large signaling complexes triggering regulated cell death. A few DNA viruses employ viral RHIMs mimicking host RHIMs and counteract cell death by i...

H5 influenza is considered a potential pandemic threat. Using deep mutational scanning, this work reveals how the >10,000 different possible amino-acid mutations in hemagglutinin affect cell entry, re...

Interactive figures and detailed results for deep mutational scanning of the HA from the clade 2.3.4.4b A/American Wigeon/South Carolina/USDA-000345-001/2021 (H5N1) strain.