Reposted by Katharina Kocher
🚀 New bioRxiv preprint!
We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states.
🔗 www.biorxiv.org/content/10.1...
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biorxiv.org
Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias
Understanding antigen reactivity is crucial for characterizing CD4+ T helper (Th) cell fate, yet conventional peptide restimulation assays introduce phenotypic bias by activating cells ex vivo. Howeve...
