Excited to share the preprint for our work on cyclosporine-based lentiviral transduction enhancer, BG147, which degrades innate immune barrier IFITM3, increasing gene delivery in gene therapy.
Huge thanks to everyone involved! @towerslab.bsky.social
www.biorxiv.org/content/10.1...
biorxiv.org
A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3
Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A analogue, optimised vi...
