iiinova — where your digital self keeps evolving

Karina Meyer-Acosta @karinameyera.bsky.social · 17/07/2025

Organoid photo and inspiration for the Cover of @stemcellreports.bsky.social July issue - many thanks to the team that made APOE4's starry night the cover! 🟢 Tuj1 (beta III tubulin for neurons, 🔵 DAPI for DNA 🔴 My favorite protein, APOE

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Karina Meyer-Acosta @karinameyera.bsky.social · 17/07/2025

My talented undergrad student, Adyasha Aruk showing off her cryomolds from organoids she cut (each mold is 1-2 hours). I might make it into a trophy 👀

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Karina Meyer-Acosta @karinameyera.bsky.social · 19/06/2025

Excited to share my first author publication exploring the neurodevelopmental role of APOE4. Using organoids, we show that APOE4 shifts the balance between neurogenesis and gliogenesis, accelerates maturation, and alters network function. Lasty, cortical APOE4 was sufficient to alter function.

cell.com

APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids

Meyer-Acosta et al. reveal that Alzheimer’s disease genetic risk factor APOE4 decreases cortical neurons and increases glia in cortical organoids and enhances GABAergic neuron maturation in ganglionic...

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Karina Meyer-Acosta @karinameyera.bsky.social · 08/05/2025

Can't believe I'm graduating with my PhD in Neuro in 10 days. I loved my dissertation project, studying the neurodevelopmental impact of APOE, and the implications on Alzheimer's. Starting over from Twitter, please help me meet more neuro enthusiasts that love research in Alz, glia, and APOE!

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Karina Meyer-Acosta @karinameyera.bsky.social · 08/05/2025

My second science card for my husband (also PhD), interested in aging research. Fun fact, naked mole rates like like 27 years, the longest relative life span to most rodent species. Anyone know why?

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Karina Meyer-Acosta @karinameyera.bsky.social · 06/05/2025

Making science cards for my favorite scientists 🤓 C. Elegans for my advisor

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Karina Meyer-Acosta @karinameyera.bsky.social · 29/01/2025

My NIH funded fellowship has allowed me to investigate how the leading Alzheimer's disease genetic risk factor, APOE4, shapes the developing human brain. 1 in 4 people are APOE4 carriers, and my research suggests that early changes in the brain may lead to later brain vulnerability.

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