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Justin

@justinhjohnson.com
225 followers 716 following 957 posts

Executive Director @ AstraZeneca | Nexus of Data, Science, Tech | Global Business Leader | Top Data Science Voice | #datascience #AI #buildinpublic #indiehacker Blog rundatarun.io BuildInPublic jandsgroupllc.com

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Justin @justinhjohnson.com · 17h
OpenAI made 25 announcements at DevDay. I read all of them. One cuts your bill: GPT-6.1 Sol at $2/$10 per million tokens. Most of the rest want your office - always-on agents, docs, meetings, logins, and a slice of your software budget.
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Justin @justinhjohnson.com · 30/09/2026
Mollick: many systems "only work today because they are built around friction." An agent moves your cash from 0.1% checking to 5%. Banks lose cheap deposits. What else breaks when agents do all the chores we skip? Tell my AI interviewer: interview.rundatarun.io/i/fee-for-n…
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Justin @justinhjohnson.com · 28/09/2026
Your AI agents leave a trail behind them. Every prompt, every tool call, every correction a person makes when the agent gets something wrong. Satya Nadella calls it exhaust, and there's a real argument it ends up worth more than the work itself.
A machine racing across a dusk sky, its exhaust plume carrying check marks and crosses, one orange stream caught in a lab flask.
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Justin @justinhjohnson.com · 25/09/2026
Anthropic now runs its own biology lab, and this week it announced the first result: 949 Claude agent sessions, 21.5 hours, and a new arrangement of genes inside a virus that infects bacteria. They named it ART.
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Justin @justinhjohnson.com · 22/09/2026
"Harness choice has little effect on task success rate, but can significantly affect the cost."
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Justin @justinhjohnson.com · 18/09/2026
On Monday a company called TypeSafe shipped a model called Jev that cannot write a sentence. Not will not. Cannot. You hand it a question and the list of answers it is allowed to give, and it hands one back, in well under a second, for a fraction of what a chatbot charges for the same judgment.
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Justin @justinhjohnson.com · 16/09/2026
Four CEOs agreed in a weekend that AI is moving too fast. Three days later Nvidia's CEO stood on the same conference stage as one of them and said we don't need any new laws.
A blank visitor badge on an empty desk inside a lit data hall.
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Justin @justinhjohnson.com · 15/09/2026
Anthropic is shipping a real plugin system for Claude Code. They're calling it Claude Mods, it lands on a scale of weeks, and it already runs today behind a flag.
Isometric illustration: a terminal window with streams of orange light flowing out, passing through three translucent glass checkpoint panels. One panel stops a stream and turns it red.
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Justin @justinhjohnson.com · 13/09/2026
On 27 August Anthropic gave AI agents a standard way to run lab equipment. Tecan, QIAGEN and Danaher are putting the driver into instruments you already own, so your lab does not adopt this. It wakes up with it.
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Justin @justinhjohnson.com · 10/09/2026
I wrote about AlphaGenome before. This week DeepMind shipped the Atlas: every possible single-letter change in the human genome, about 9 billion, precomputed.
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Justin @justinhjohnson.com · 08/09/2026
OpenAI put out two posts on Sunday and I read both twice. One is a wall of charts about how much of its research is now done by agents. The other is its chief scientist saying he can no longer see what those agents are thinking.
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Justin @justinhjohnson.com · 31/08/2026
Generation got cheap. Selection didn't. That gap is the whole job now, and a lot of us are still staffing for the old one.
Run Data Run card: The Word I Didn't Write
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Justin @justinhjohnson.com · 29/08/2026
Cisco gave all 90,000 of its employees a personal AI agent. The best quote is the CFO's, not the CTO's: "It's not going to burn a whole bunch of tokens with frontier models."
Flat vector diagram on deep navy. One orange line enters from the left and meets a small routing node, which fans out to three small glowing orange model blocks. Two much larger grey model blocks sit off to the side, unlit and unconnected.
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Justin @justinhjohnson.com · 13/08/2026
Encryption was never the weak part. Scope was.
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Justin @justinhjohnson.com · 09/08/2026
A cast is the right call while the bone is broken. Leave it on past healing and the muscle underneath wastes.
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Justin @justinhjohnson.com · 06/08/2026
Updated slopless with my hard won principles. 78 of them, numbered, each bought by a specific failure.
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Justin @justinhjohnson.com · 06/08/2026
Twelve words from Peter Steinberger got 2.9 million views last month and handed us a whole new discipline. Graph engineering. Within two days it had three competing definitions and two Stanford studies proving it works.
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Justin @justinhjohnson.com · 05/08/2026
Last morning of the contest. Four publishing slots left, five hours to deadline, and my pipeline had spent six hours insisting it had nothing left to publish.
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Justin @justinhjohnson.com · 04/08/2026
Your AI setup is probably more portable than you think, and I proved it for less than the price of a snack.
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Justin @justinhjohnson.com · 30/07/2026
www.alphaxiv.org/abs/2607.21461 Most agents compact context when they run out of room. AREX trains the model to compact because it decided what it had verified.
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Justin @justinhjohnson.com · 27/07/2026
The enterprise prediction layer got bought this quarter, and almost nobody has independently checked what was bought.
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Justin @justinhjohnson.com · 26/07/2026
Pick a paper from a major AI conference. Try to break it. Publish whatever happened, mess included. That is the whole contest Hugging Face and alphaXiv are running until next Sunday, and an automated judge scores it claim by claim.
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Justin @justinhjohnson.com · 21/07/2026
If you lead a team and you have never built anything with these tools yourself, there is a decent chance you are the reason your team hasn't either.
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Justin @justinhjohnson.com · 21/07/2026
A team at Cognition just swapped in a model that costs about twice as much per token, and their bill went down. Not their quality. Their bill. The expensive model, wired up right, came out better and cheaper than the cheap model on its own.
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Justin @justinhjohnson.com · 21/07/2026
The open-weight frontier had a week. Thinking Machines Lab shipped Inkling, 975B params with 41B active, multimodal. Kimi K3 dropped right behind it.
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Justin @justinhjohnson.com · 20/07/2026
A month ago I put Claudelicious online, the open cookbook for the Claude Code harness I run. Here's what the harness did since.
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Justin @justinhjohnson.com · 20/07/2026
In 2016 an OpenAI agent was told to win a boat race. Instead it found a lagoon where three targets respawned forever, spun in a circle farming them, caught fire, never finished a lap, and scored about twenty percent above the average human. It did exactly what it was asked.
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Justin @justinhjohnson.com · 20/07/2026
Seven weeks ago Anthropic shipped a way for Claude to split a job across dozens of AI workers at once and check its own work. I called the economics on day one, and I was right about the easy part. Running it every day since taught me the part I got wrong.
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Justin @justinhjohnson.com · 17/07/2026
"A CPU-only PyTorch wheel installs without a single error and runs twenty times slower in total silence."
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Justin @justinhjohnson.com · 17/07/2026
Three numbers in sixteen days. Anthropic's Claude Code lead published an adoption ladder this week and opened it with a line he says he hears constantly: one person is 10x'ing their output, and the rest of the org hasn't caught up.
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Justin @justinhjohnson.com · 15/07/2026
A 27B reasoning model ran fully local on my 36GB MacBook at ~20 tok/s. Not a 4-bit quant: PrismML's Bonsai 27B is Qwen3.6-27B with natively binary/ternary weights, 94.6% of FP16 at 5.9GB. I wired it into a local tool loop over my own vault. glyf.cc/bonsai27b
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Justin @justinhjohnson.com · 15/07/2026
Everyone in AI is talking about "the loop" right now. Anthropic shipped it as a feature. The slogan going around is that the winners will not have the smartest model, they will have the best loop.
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Justin @justinhjohnson.com · 14/07/2026
There are roughly 200,000 eye specialists on Earth, and well over a billion people living with diabetes and high blood pressure, the diseases that take sight before anyone catches them. The math does not work.
Four parallel lanes with an orange seam cutting across them.
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Justin @justinhjohnson.com · 12/07/2026
Four AI systems that do science on their own cleared peer review in the last four months. Every single one of them was already more than a year old.
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Justin @justinhjohnson.com · 12/07/2026
An AI system called Robin was handed the name of a disease and told to find a treatment.
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Justin @justinhjohnson.com · 09/07/2026
People keep asking how I stay current on AI. For a long time I answered badly. I said I read a lot, which is true and completely useless to the person asking.
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Justin @justinhjohnson.com · 08/07/2026
Our autonomous research engine ran more than six hundred experiments in a couple of days and never once looked unhealthy. The dashboard stayed green the whole time. Almost every one of those experiments was the same experiment wearing different labels.
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Justin @justinhjohnson.com · 07/07/2026
for months i've had an AI running its own research. it invents experiments, runs them, red-teams its own results, learns, repeats. around the clock, healing itself when it crashes.
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Justin @justinhjohnson.com · 07/07/2026
"The first time you see an engineer build something in 45 minutes that would have taken a week a year ago, but then see it not ship for another 6 weeks, you will be radicalized."
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Justin @justinhjohnson.com · 06/07/2026
Today I put out the two things that sit next to my book: an essay and a field guide.
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Justin @justinhjohnson.com · 01/07/2026
My book is out today: Builder-Leader: The AI Exoskeleton That Crosses the Gap. Paperback is live right now, Kindle ships tomorrow.
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Justin @justinhjohnson.com · 30/06/2026
Anthropic shipped Claude Science today. It is an AI workbench for scientists, built to compress the tedious 80 percent of research work: the literature synthesis, the pipeline glue, the figure iteration, the notebook plumbing that eats a day and produces nothing.
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Justin @justinhjohnson.com · 30/06/2026
NVIDIA let us borrow some iron: eight H100 GPUs on a grant clock that doesn't stop. So the test isn't how fast the node is, it's how full we keep it.
The Borrowed Iron series hero: an eight-GPU NVIDIA node powering SocialEyes retinal-AI research.
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Justin @justinhjohnson.com · 28/06/2026
NVIDIA just handed a small global-health startup I work with a node of eight H100 GPUs for two months. No invoice. The crew putting it to work is five people: me, the founder, and three high-school interns.
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Justin @justinhjohnson.com · 27/06/2026
The new AIXplore is live. I rebuilt it from the ground up into a lab notebook rather than a blog: interactive widgets you can drive, Tufte-style margin notes for citations and asides, and side quests that open the deep technical detours without cluttering the main read.
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Justin @justinhjohnson.com · 26/06/2026
NatureBench: can coding agents move beyond reproduction into actual discovery? 90 tasks from real Nature papers, 6 scientific domains, each scored against published SOTA. Finally the right test. huggingface.co/papers/2606.24530
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Justin @justinhjohnson.com · 26/06/2026
New benchmark: NatureBench drops coding agents into 90 real Nature-family problems behind an information firewall, so they have to *discover* the method, not copy it from the paper. Best agent (Claude Opus 4.7) beats published SOTA on 17.8% of tasks. Ties it on ~48%.
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Justin @justinhjohnson.com · 25/06/2026
I wrote a new piece about the harness.
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Justin @justinhjohnson.com · 24/06/2026
New AIXplore: reasoning post-training has split into two camps, and the split is the reward, not the architecture.
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Justin @justinhjohnson.com · 23/06/2026
I'm on sabbatical. For most people that means rest. For me it means building full-time for the first time in years.
A maker's desk at night, laptop glowing, sparks of light rising into a constellation of connected nodes
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