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Jen Herman 🌪️

@jukebarosh.bsky.social
712 followers 178 following 1.2K posts

Mostly Bacillus | unpublished data | hypotheses | wild ideas | sand-outta-box | who wants 2 bet? | 🧠🔥🐳 | Zinc ♡ | No one important | www.hermanlab.com |

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Jen Herman 🌪️ @jukebarosh.bsky.social · 10h
We can reproduce reduced accumulation of pulcherrmin in the 3610 yvmA mutant on MSgg, but weirdly the complemented strain is even lighter than the yvmA knockout. I cannot make these data fit a model where yvmA is a PA exporter. Maybe an exporter & importer, but maybe not PA at all?
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Jen Herman 🌪️ @jukebarosh.bsky.social · 11h
When we knockout yvmA in the 168 background, it overaccumulates extracellular pulcherrimin compared to the wildtype parent on our minimal medium. We can complement the phenotype expressing yvmA in trans. Doesn't really make sense to me that it's an exporter of pulcherriminic acid in 168
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Jen Herman 🌪️ @jukebarosh.bsky.social · 06/10/2026
Oh God... just watched the tortuga episode
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Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026
I didn't catch much - need to get back on my German
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Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026
0--> -1 😆😭
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Michelle Fry @myfry.bsky.social · 02/10/2026
1/ 🧵 Two classic mitochondrial pathways the TCA cycle and OXPHOS are taught as linked but distinct pathways. I’m happy to share our new work out in @cp-cell.bsky.social showing that in Acanthamoeba they're physically linked—with a TCA enzyme incorporated in ATP synthase. www.cell.com/cell/fulltex...
cell.com
Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS
Acanthamoeba castellanii, a pathogenic amoeba, belongs to an evolutionary branch distinctly removed from humans and fungi. Cryo-EM of the organism’s ATP synthase enzyme using raw mitochondrial lysates...
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Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026
😆 At least in Bsub I hypothesize they are extracellular polymer - PGA & maybe some kind of EPS (at least dependent on one). Neither conduit-tubes, nor manifestations of cell death. Easy to check if one has the microscopy optimized: K/o pgsB
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Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026
Because, I am not a machine, that is why.
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Zoe McElligott @nanopharmnc.bsky.social · 04/10/2026
what could possibly go wrong....
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Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026
I was going to say "you can be anything you want to be!"
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Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026
PGA
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Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026
All my best memories I was dancing
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elizabethginexi.bsky.social @elizabethginexi.bsky.social · 04/10/2026
NIH’s move toward multiyear funding is a major reason for the drop in grant numbers: The agency now commits several years of funding at once to fewer awards, rather than paying for projects one year at a time. www.the-scientist.com/federal-rese...
the-scientist.com
NIH Grant Awards Fall to a Six-Year Low in FY2026 | The Scientist
A public dataset from Grant Witness shows NIH has issued about 11 percent fewer grant awards this fiscal year than its five-year average pace.
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Ákos T Kovács @evolvedbiofilm.bsky.social · 04/10/2026
When the morning walk with 🐕 feels like walking by a painting
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Jen Herman 🌪️ @jukebarosh.bsky.social · 04/10/2026
Wow!
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Brett Baker @archaeal.bsky.social · 02/10/2026
Two Assistant Professor Positions in Evolutionary Biology and Mechanistic Processes - including microbes! faculty.utexas.edu/career/191568
faculty.utexas.edu
Faculty Careers - The University of Texas at Austin
Unleash your intellectual power by joining a world-renowned faculty that is solving the world's most urgent problems. At UT Austin, we provide you the freedom to blaze trails, follow your curiosity, e...
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David Ho @davidho.bsky.social · 03/10/2026
I don’t think everyone realizes how bad things are for US science: For the fiscal year that just ended, the Trump regime withheld $1.4 billion from the National Science Foundation’s research budget, which is about 1/5 of its primary research budget.
nytimes.com
National Science Foundation Diverted $1.4 Billion in Science Funds Mandated by Congress (Gift Article)
The move, affecting about one-fifth of the National Science Foundation’s primary research budget, is the latest sign of how the White House is asserting more control over grants.
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Carolyn Rasmussen @carolynplants.bsky.social · 03/10/2026
No cheating. Share the last photo of the sky from your camera roll.
Sunset oranges blues and yellows with some houses and palm trees
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
Heh
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
Hello, 🍎
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Jarvis Googoo @jarvisgoogoo.com · 03/10/2026
Amazing editorial cartoon re artificial intelligence by @mackinnonart.bsky.social
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
Even when you tell people directly and they are close family, they still don't think it is happening. It isn't in their mainstream news & their reps aren't pushing back, so it isn't real. They think if something is really bad, there is kickback. Not so much when the govt actively targets dissent
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
😮
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
😮 is there reason to think they are not?
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
I liked that there is interaction here
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
I have on list but read it was prequel so thought I would watch in order? (Or not order?)
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
Whoa, intense! But even the cats are digging
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
Need some new tunes, preferably upbeat. Please suggest!
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
Just started watching breaking bad. Very confused how this can go on 6 seasons
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Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026
me: cool & smart them: voilá! hallway art
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Jen Herman 🌪️ @jukebarosh.bsky.social · 02/10/2026
Was sitting on chair backwards in CS class freshman year (cool-like). Poked hand through top & it got stuck. When bell rang, the jocks in class picked me up & put me in the hallway. Mui embarrassing
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STCmicrobeblog @stcmicrobeblog.bsky.social · 02/10/2026
#MicroSky
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Kelly Dawe @corncolors.bsky.social · 01/10/2026
The UGA Genetics Department is hiring! Please help spread the word. We have an opening for an Associate Professor/Professor in Genetics, Synthetic Biology, and Biological Engineering. See ad for details – and join us here in Athens, GA!
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Molecular Microbiology @molmicrounihoh.bsky.social · 01/10/2026
🫴 Physiological Roles of Carbonic Anhydrases and an MpsAB-like Bicarbonate Transporter in Bacillus subtilis: 👇 www.biorxiv.org/content/10.6... #subtiwiki #subtilis #CO2
biorxiv.org
Physiological Roles of Carbonic Anhydrases and an MpsAB-like Bicarbonate Transporter in Bacillus subtilis
Carbonic anhydrase (E.C. 4.2.1.1) is an enzyme that catalyzes the reversible hydration of CO2 to carbonic acid (H2CO3), which dissociates to bicarbonate (HCO3−) at intracellular pH. Copious amounts of...
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Dr. D Boulware, MD MPH @drboulware.bsky.social · 01/10/2026
NIH Funding rate of Early Stage Investigators (ESI). 2025 was a major drop. 2026 will be worse.
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Jen Herman 🌪️ @jukebarosh.bsky.social · 01/10/2026
ND, which stands for no dice 🚫🎲🎲
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Jen Herman 🌪️ @jukebarosh.bsky.social · 01/10/2026
I see one positive change. At present, changes to IBC permit (eg. addition of BSL1 organism or even protein expression plasmid) requires the full IBC meet (which only happens monthly here). This change would allow one or a subset of IBC members to approve certain changes.
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Jennifer Biddle @jenbiddle.bsky.social · 01/10/2026
Hey Biologists : Have you made any comments on the NIH Biosafety Policy for Biohazards? Because some of the changes are REDONKULOUS - and there are only 40 comments on file - Submit comments by Oct 19! osp.od.nih.gov/comment-form.... 🦠 #microsky
osp.od.nih.gov
Comment Form: Draft NIH Biosafety Policy for Research Involving Biohazards
Request for Information: Draft NIH Biosafety Policy for Research Involving Biohazards
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Molecular Microbiology @molmicrounihoh.bsky.social · 01/10/2026
😎 Read this: The phenotypic landscape of the model firmicute Bacillus subtilis! In @pnas.org : 👇👇 www.pnas.org/doi/10.1073/... #subtiwiki #subtilis
pnas.org
The phenotypic landscape of the model firmicute Bacillus subtilis | PNAS
Firmicutes are gram-positive bacteria with important roles in human health, disease, and industry. However, more than a quarter of genes in the mod...
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Jen Herman 🌪️ @jukebarosh.bsky.social · 30/09/2026
Whoop, Jason!
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Center for Phage Technology @phagetechnology.bsky.social · 30/09/2026
The CPT's own @jasonjgill.bsky.social was interviewed in Wired magazine about a new class of retron-like reverse transcriptases reported by Anthropic last week. These enzymes were identified in our 2021 paper on the MarsHill-like jumbo phages infecting S. aureus. www.wired.com/story/anthro...
wired.com
Anthropic Says It Discovered a Crispr-Like System. Now What?
“The experiments are still in the queue. The PR is already live,” says one expert.
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Jen Herman 🌪️ @jukebarosh.bsky.social · 30/09/2026
Just put it in an ice bucket in the sink so you don't crack the sink & pipes & give the building manager night terrors. Happy haunting
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Vivek Mutalik @vivekmutalik.bsky.social · 29/09/2026
In our brand new 🥳 review, @hemaa-selvakumar.bsky.social & team pull a scattered literature in phage biology into a coherent framework for scaling up to engineering complex communities. We poured our hearts into this to share challenges & future opportunities for the nextGen!
Next generation application space with systematic characterization of phage-host interaction landscapes.
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Jen Herman 🌪️ @jukebarosh.bsky.social · 29/09/2026
I used to joke "Just install a chip in me already!" But now I am serious: just install the chip in me. Enough
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Jen Herman 🌪️ @jukebarosh.bsky.social · 29/09/2026
A trackable metric... I'd like credit for my time! We have different (and incompatible!) logons for the college and university. I'd bet a donut multifactor cross adds up to at least one WEEK/yr.
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Molecular Microbiology @molmicrounihoh.bsky.social · 29/09/2026
Nuclear cGAS inhibits stimulation-induced inflammatory gene transcription via HDAC1: www.pnas.org/doi/10.1073/... #cGAMP @pnas.org
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Jen Herman 🌪️ @jukebarosh.bsky.social · 29/09/2026
Probably many such cases - makes me think about abortive infection, for example. Mess with the nucleotide pools & you mess with txn/protein synthesis/DNA replication coupling. Lysis (true death) only happens if cells can't manage the stress.
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Jen Herman 🌪️ @jukebarosh.bsky.social · 29/09/2026
Reading more closely - I would expect that the inability to make cfu in this case does not = lysis/death, at least for the case of OverExpression. I It's more like OE creates zombies that still have a chance to mutate & return to a reproductive state.
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Jen Herman 🌪️ @jukebarosh.bsky.social · 29/09/2026
:(
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Jen Herman 🌪️ @jukebarosh.bsky.social · 28/09/2026
AI and Education – Report of MIT’s Ad Hoc Committee on AI Use in Teaching, Learning, and Research Training share.google/B6yUKbSvcvzn... Read the whole thing. Has reduced the unease & uncertainty exactly 0%
share.google
AI and Education – Report of MIT’s Ad Hoc Committee on AI Use in Teaching, Learning, and Research Training
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