Jen Herman 🌪️ @jukebarosh.bsky.social · 10hWe can reproduce reduced accumulation of pulcherrmin in the 3610 yvmA mutant on MSgg, but weirdly the complemented strain is even lighter than the yvmA knockout. I cannot make these data fit a model where yvmA is a PA exporter. Maybe an exporter & importer, but maybe not PA at all? 100
Jen Herman 🌪️ @jukebarosh.bsky.social · 11hWhen we knockout yvmA in the 168 background, it overaccumulates extracellular pulcherrimin compared to the wildtype parent on our minimal medium. We can complement the phenotype expressing yvmA in trans. Doesn't really make sense to me that it's an exporter of pulcherriminic acid in 168 110
Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026I didn't catch much - need to get back on my German 000
Reposted by Jen Herman 🌪️Michelle Fry @myfry.bsky.social · 02/10/20261/ 🧵 Two classic mitochondrial pathways the TCA cycle and OXPHOS are taught as linked but distinct pathways. I’m happy to share our new work out in @cp-cell.bsky.social showing that in Acanthamoeba they're physically linked—with a TCA enzyme incorporated in ATP synthase. www.cell.com/cell/fulltex...cell.comAcanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOSAcanthamoeba castellanii, a pathogenic amoeba, belongs to an evolutionary branch distinctly removed from humans and fungi. Cryo-EM of the organism’s ATP synthase enzyme using raw mitochondrial lysates... 15326
Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026😆 At least in Bsub I hypothesize they are extracellular polymer - PGA & maybe some kind of EPS (at least dependent on one). Neither conduit-tubes, nor manifestations of cell death. Easy to check if one has the microscopy optimized: K/o pgsB 010
Reposted by Jen Herman 🌪️Zoe McElligott @nanopharmnc.bsky.social · 04/10/2026what could possibly go wrong.... 022
Jen Herman 🌪️ @jukebarosh.bsky.social · 05/10/2026I was going to say "you can be anything you want to be!" 020
Reposted by Jen Herman 🌪️elizabethginexi.bsky.social @elizabethginexi.bsky.social · 04/10/2026NIH’s move toward multiyear funding is a major reason for the drop in grant numbers: The agency now commits several years of funding at once to fewer awards, rather than paying for projects one year at a time. www.the-scientist.com/federal-rese...the-scientist.comNIH Grant Awards Fall to a Six-Year Low in FY2026 | The ScientistA public dataset from Grant Witness shows NIH has issued about 11 percent fewer grant awards this fiscal year than its five-year average pace. 13736
Reposted by Jen Herman 🌪️Ákos T Kovács @evolvedbiofilm.bsky.social · 04/10/2026When the morning walk with 🐕 feels like walking by a painting 1221
Reposted by Jen Herman 🌪️Brett Baker @archaeal.bsky.social · 02/10/2026Two Assistant Professor Positions in Evolutionary Biology and Mechanistic Processes - including microbes! faculty.utexas.edu/career/191568faculty.utexas.eduFaculty Careers - The University of Texas at AustinUnleash your intellectual power by joining a world-renowned faculty that is solving the world's most urgent problems. At UT Austin, we provide you the freedom to blaze trails, follow your curiosity, e... 03848
Reposted by Jen Herman 🌪️David Ho @davidho.bsky.social · 03/10/2026I don’t think everyone realizes how bad things are for US science: For the fiscal year that just ended, the Trump regime withheld $1.4 billion from the National Science Foundation’s research budget, which is about 1/5 of its primary research budget.nytimes.comNational Science Foundation Diverted $1.4 Billion in Science Funds Mandated by Congress (Gift Article)The move, affecting about one-fifth of the National Science Foundation’s primary research budget, is the latest sign of how the White House is asserting more control over grants. 201826906
Reposted by Jen Herman 🌪️Carolyn Rasmussen @carolynplants.bsky.social · 03/10/2026No cheating. Share the last photo of the sky from your camera roll. 131
Reposted by Jen Herman 🌪️Jarvis Googoo @jarvisgoogoo.com · 03/10/2026Amazing editorial cartoon re artificial intelligence by @mackinnonart.bsky.social 191327454
Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026Even when you tell people directly and they are close family, they still don't think it is happening. It isn't in their mainstream news & their reps aren't pushing back, so it isn't real. They think if something is really bad, there is kickback. Not so much when the govt actively targets dissent 040
Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026I have on list but read it was prequel so thought I would watch in order? (Or not order?) 100
Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026Need some new tunes, preferably upbeat. Please suggest! 100
Jen Herman 🌪️ @jukebarosh.bsky.social · 03/10/2026Just started watching breaking bad. Very confused how this can go on 6 seasons 220
Jen Herman 🌪️ @jukebarosh.bsky.social · 02/10/2026Was sitting on chair backwards in CS class freshman year (cool-like). Poked hand through top & it got stuck. When bell rang, the jocks in class picked me up & put me in the hallway. Mui embarrassing 330
Reposted by Jen Herman 🌪️Kelly Dawe @corncolors.bsky.social · 01/10/2026The UGA Genetics Department is hiring! Please help spread the word. We have an opening for an Associate Professor/Professor in Genetics, Synthetic Biology, and Biological Engineering. See ad for details – and join us here in Athens, GA! 24174
Reposted by Jen Herman 🌪️Molecular Microbiology @molmicrounihoh.bsky.social · 01/10/2026🫴 Physiological Roles of Carbonic Anhydrases and an MpsAB-like Bicarbonate Transporter in Bacillus subtilis: 👇 www.biorxiv.org/content/10.6... #subtiwiki #subtilis #CO2biorxiv.orgPhysiological Roles of Carbonic Anhydrases and an MpsAB-like Bicarbonate Transporter in Bacillus subtilisCarbonic anhydrase (E.C. 4.2.1.1) is an enzyme that catalyzes the reversible hydration of CO2 to carbonic acid (H2CO3), which dissociates to bicarbonate (HCO3−) at intracellular pH. Copious amounts of... 011
Reposted by Jen Herman 🌪️Dr. D Boulware, MD MPH @drboulware.bsky.social · 01/10/2026NIH Funding rate of Early Stage Investigators (ESI). 2025 was a major drop. 2026 will be worse. 34442
Jen Herman 🌪️ @jukebarosh.bsky.social · 01/10/2026I see one positive change. At present, changes to IBC permit (eg. addition of BSL1 organism or even protein expression plasmid) requires the full IBC meet (which only happens monthly here). This change would allow one or a subset of IBC members to approve certain changes. 001
Reposted by Jen Herman 🌪️Jennifer Biddle @jenbiddle.bsky.social · 01/10/2026Hey Biologists : Have you made any comments on the NIH Biosafety Policy for Biohazards? Because some of the changes are REDONKULOUS - and there are only 40 comments on file - Submit comments by Oct 19! osp.od.nih.gov/comment-form.... 🦠 #microskyosp.od.nih.govComment Form: Draft NIH Biosafety Policy for Research Involving BiohazardsRequest for Information: Draft NIH Biosafety Policy for Research Involving Biohazards 2818
Reposted by Jen Herman 🌪️Molecular Microbiology @molmicrounihoh.bsky.social · 01/10/2026😎 Read this: The phenotypic landscape of the model firmicute Bacillus subtilis! In @pnas.org : 👇👇 www.pnas.org/doi/10.1073/... #subtiwiki #subtilispnas.orgThe phenotypic landscape of the model firmicute Bacillus subtilis | PNASFirmicutes are gram-positive bacteria with important roles in human health, disease, and industry. However, more than a quarter of genes in the mod... 021
Reposted by Jen Herman 🌪️Center for Phage Technology @phagetechnology.bsky.social · 30/09/2026The CPT's own @jasonjgill.bsky.social was interviewed in Wired magazine about a new class of retron-like reverse transcriptases reported by Anthropic last week. These enzymes were identified in our 2021 paper on the MarsHill-like jumbo phages infecting S. aureus. www.wired.com/story/anthro...wired.comAnthropic Says It Discovered a Crispr-Like System. Now What?“The experiments are still in the queue. The PR is already live,” says one expert. 133
Jen Herman 🌪️ @jukebarosh.bsky.social · 30/09/2026Just put it in an ice bucket in the sink so you don't crack the sink & pipes & give the building manager night terrors. Happy haunting 021
Reposted by Jen Herman 🌪️Vivek Mutalik @vivekmutalik.bsky.social · 29/09/2026In our brand new 🥳 review, @hemaa-selvakumar.bsky.social & team pull a scattered literature in phage biology into a coherent framework for scaling up to engineering complex communities. We poured our hearts into this to share challenges & future opportunities for the nextGen! 22913
Jen Herman 🌪️ @jukebarosh.bsky.social · 29/09/2026I used to joke "Just install a chip in me already!" But now I am serious: just install the chip in me. Enough 010
Jen Herman 🌪️ @jukebarosh.bsky.social · 29/09/2026A trackable metric... I'd like credit for my time! We have different (and incompatible!) logons for the college and university. I'd bet a donut multifactor cross adds up to at least one WEEK/yr. 120
Reposted by Jen Herman 🌪️Molecular Microbiology @molmicrounihoh.bsky.social · 29/09/2026Nuclear cGAS inhibits stimulation-induced inflammatory gene transcription via HDAC1: www.pnas.org/doi/10.1073/... #cGAMP @pnas.orgpnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans... 001
Jen Herman 🌪️ @jukebarosh.bsky.social · 29/09/2026Probably many such cases - makes me think about abortive infection, for example. Mess with the nucleotide pools & you mess with txn/protein synthesis/DNA replication coupling. Lysis (true death) only happens if cells can't manage the stress. 010
Jen Herman 🌪️ @jukebarosh.bsky.social · 29/09/2026Reading more closely - I would expect that the inability to make cfu in this case does not = lysis/death, at least for the case of OverExpression. I It's more like OE creates zombies that still have a chance to mutate & return to a reproductive state. 110
Jen Herman 🌪️ @jukebarosh.bsky.social · 28/09/2026AI and Education – Report of MIT’s Ad Hoc Committee on AI Use in Teaching, Learning, and Research Training share.google/B6yUKbSvcvzn... Read the whole thing. Has reduced the unease & uncertainty exactly 0%share.googleAI and Education – Report of MIT’s Ad Hoc Committee on AI Use in Teaching, Learning, and Research Training 000