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Prof. Jagan Srinivasan

@jsrinivasanwpi.bsky.social
167 followers 199 following 19 posts

An immigrant neuroscientist who endeavors to understand the brain. Systems Neuroscience Laboratory, Worcester Polytechnic Institute in Massachusetts, USA. A son, husband, father, and an immigrant !

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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 02/04/2026
i second this view Harmit!
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 09/03/2026
we still won Comprehensively Harmit! our bowlers did well to not only defend but metaphorically thrash them!
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Reposted by Prof. Jagan Srinivasan
Genetics Society of America @genetics-gsa.bsky.social · 13/10/2025
In #GENETICS, @jsrinivasanwpi.bsky.social and the team present a rescue-by-feeding approach, showing that feeding engineered E. coli containing neuropeptides to #Celegans mutants can successfully rescue behavior defects in worms. buff.ly/Qdw9Nsq
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 08/05/2025
A new story out of our lab from the talented grad student Elizabeth Diloreto in collaboration with the Javier Irazoqui lab at UMASSCHAN. www.biorxiv.org/content/10.1...
biorxiv.org
Staphylococcus aureus-Induced Degeneration of Nociceptive Neurons in Caenorhabditis elegans
Background In all animals, the nervous system senses microbial signals to influence host defense. Despite emerging as important sensors of infection to regulate immunity and inflammation, the mechanis...
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 08/05/2025
Now have to get the book!
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 20/03/2025
This is really a cool story as to how serotonin affects sensory processing of conflicting stimuli!
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 20/03/2025
This work is a significant part of her PhD thesis. She worked with a high school student, Sophia Guerra, to dissect the signaling mechanisms underlying serotonin signaling and discovered that ADF sensory neurons regulate decisions in response to opposing stimuli!
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 20/03/2025
Two papers in two weeksAnother paper from our lab is out for review! This paper unravels how serotonin signaling via specific neurons is involved in deciphering conflicting olfactory stimuli. Great work from my grad student Caroline Muirhead, the lead author. www.biorxiv.org/content/10.1...
biorxiv.org
Serotonergic signaling governs C. elegans sensory response to conflicting olfactory stimuli
Neural circuits that consolidate sensory cues are essential for neurological functioning. Neural circuits that perform sensory integration can vary greatly because the sensory processing regions of th...
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 20/03/2025
Congrats on this interesting manuscript!👏
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Reposted by Prof. Jagan Srinivasan
Sam Connell @samuelconnell.3i.social · 17/03/2025
Holy microscopes Batman. This is shockingly good and unexpected news. Let me know if you'd like an update to your @the.3i.social microscope or a replacement to some obsolete microscopy equipment in your lab. 3i makes modular tools that can fit quite cleanly into the supplement program. #specificaims
media.tenor.com
a man in a robin costume is holding a sword and says holy smoke
ALT: a man in a robin costume is holding a sword and says holy smoke
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/03/2025
While this manuscript contains more questions than answers, it is a great new tool for the community to test the function of individual peptides. Additionally, this method can be used for overexpression studies of neuropeptides as shown by our colleagues at BCM @rnareylab.bsky.social !
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/03/2025
In this manuscript, which has been a few years in the development, we engineered a vector to code individual peptides. This vector was then transformed into bacteria and fed to loss of function neuropeptide worms. Lo and Behold, the mutant worms displayed rescue of the phenotype
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/03/2025
Exciting new work from our lab in collaboration with the @rnareylab.bsky.social labs. www.biorxiv.org/content/10.1...
biorxiv.org
Harnessing Microbial Tools: Escherichia coli as a Vehicle for Neuropeptide Functional Analysis in Caenorhabditis elegans
Animals respond to changes in their environment and internal states via neuromodulation. Neuropeptides modulate neural circuits with flexibility because one gene can produce either multiple copies of ...
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/03/2025
We are lucky to have such good collaborators!!👏
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 10/03/2025
A chocolate mousse cake and Chicken biriyani!
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 16/01/2025
i completely understand
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 25/12/2024
Hope he feels better soon!!
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 25/11/2024
will do rightaway
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 19/11/2024
same here Javier!
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 15/11/2024
we are doomed.
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Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/11/2024
Hello Blue sky universe! Navigating this social space for colleagues and friends!
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