Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 09/03/2026we still won Comprehensively Harmit! our bowlers did well to not only defend but metaphorically thrash them! 000
Reposted by Prof. Jagan SrinivasanGenetics Society of America @genetics-gsa.bsky.social · 13/10/2025In #GENETICS, @jsrinivasanwpi.bsky.social and the team present a rescue-by-feeding approach, showing that feeding engineered E. coli containing neuropeptides to #Celegans mutants can successfully rescue behavior defects in worms. buff.ly/Qdw9Nsq 074
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 08/05/2025A new story out of our lab from the talented grad student Elizabeth Diloreto in collaboration with the Javier Irazoqui lab at UMASSCHAN. www.biorxiv.org/content/10.1...biorxiv.orgStaphylococcus aureus-Induced Degeneration of Nociceptive Neurons in Caenorhabditis elegansBackground In all animals, the nervous system senses microbial signals to influence host defense. Despite emerging as important sensors of infection to regulate immunity and inflammation, the mechanis... 131
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 20/03/2025This is really a cool story as to how serotonin affects sensory processing of conflicting stimuli! 020
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 20/03/2025This work is a significant part of her PhD thesis. She worked with a high school student, Sophia Guerra, to dissect the signaling mechanisms underlying serotonin signaling and discovered that ADF sensory neurons regulate decisions in response to opposing stimuli! 020
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 20/03/2025Two papers in two weeksAnother paper from our lab is out for review! This paper unravels how serotonin signaling via specific neurons is involved in deciphering conflicting olfactory stimuli. Great work from my grad student Caroline Muirhead, the lead author. www.biorxiv.org/content/10.1...biorxiv.orgSerotonergic signaling governs C. elegans sensory response to conflicting olfactory stimuliNeural circuits that consolidate sensory cues are essential for neurological functioning. Neural circuits that perform sensory integration can vary greatly because the sensory processing regions of th... 241
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 20/03/2025Congrats on this interesting manuscript!👏 110
Reposted by Prof. Jagan SrinivasanSam Connell @samuelconnell.3i.social · 17/03/2025Holy microscopes Batman. This is shockingly good and unexpected news. Let me know if you'd like an update to your @the.3i.social microscope or a replacement to some obsolete microscopy equipment in your lab. 3i makes modular tools that can fit quite cleanly into the supplement program. #specificaimsmedia.tenor.coma man in a robin costume is holding a sword and says holy smokeALT: a man in a robin costume is holding a sword and says holy smoke 1114
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/03/2025While this manuscript contains more questions than answers, it is a great new tool for the community to test the function of individual peptides. Additionally, this method can be used for overexpression studies of neuropeptides as shown by our colleagues at BCM @rnareylab.bsky.social ! 110
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/03/2025In this manuscript, which has been a few years in the development, we engineered a vector to code individual peptides. This vector was then transformed into bacteria and fed to loss of function neuropeptide worms. Lo and Behold, the mutant worms displayed rescue of the phenotype 100
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/03/2025Exciting new work from our lab in collaboration with the @rnareylab.bsky.social labs. www.biorxiv.org/content/10.1...biorxiv.orgHarnessing Microbial Tools: Escherichia coli as a Vehicle for Neuropeptide Functional Analysis in Caenorhabditis elegansAnimals respond to changes in their environment and internal states via neuromodulation. Neuropeptides modulate neural circuits with flexibility because one gene can produce either multiple copies of ... 173
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/03/2025We are lucky to have such good collaborators!!👏 040
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 10/03/2025A chocolate mousse cake and Chicken biriyani! 030
Prof. Jagan Srinivasan @jsrinivasanwpi.bsky.social · 13/11/2024Hello Blue sky universe! Navigating this social space for colleagues and friends! 140