jsb-lab.bsky.social @jsb-lab.bsky.social · 16/05/2025Not yet in the preprint: Mass spectrometry confirmed the highly specific degradation of one target protein out of 9,677 human proteins that were quantified in cell lysates 100
jsb-lab.bsky.social @jsb-lab.bsky.social · 16/05/2025Fusing AI-binders to a mutant FKBP12 domain enabled drug-controlled degradation of the endogenous target protein in human macrophages 100
jsb-lab.bsky.social @jsb-lab.bsky.social · 16/05/2025Coupling AI-binders to EGFP enabled the antibody-free staining of an endogenous protein in primary human macrophages 100
jsb-lab.bsky.social @jsb-lab.bsky.social · 16/05/2025Using Transposon-Display, we identified binders for four intracellular human proteins and further improved them by saturation mutagenesis 100
jsb-lab.bsky.social @jsb-lab.bsky.social · 16/05/2025We developed a technology called Transposon-Display, which couples AI binders to their own DNA for pooled screening 120
