iiinova — where your digital self keeps evolving

Reposted by Jared Mayers, MD, PhD

Lucas Sullivan @lucasbsullivan.bsky.social · 20/02/2025

Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability. Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!

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Reposted by Jared Mayers, MD, PhD

Lucas Sullivan @lucasbsullivan.bsky.social · 20/02/2025

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation.

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Reposted by Jared Mayers, MD, PhD

Behnam Nabet @behnamnabet.bsky.social · 27/12/2024

🧪 Ready, set, degrade! So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer. Link: www.jci.org/articles/vie...

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Reposted by Jared Mayers, MD, PhD

Saloni @scientificdiscovery.dev · 20/12/2024

It's estimated that around 13% of cancers overall are caused by infections. This is an area where prevention can be very powerful: by tackling the infections that cause them, we can stop these cancers before they start. 🧵

Certain pathogens, like viruses and bacteria, can cause long-term inflammation or directly damage DNA, in ways that eventually lead to cancer.

For example, hepatitis B and C viruses, which can spread via blood, are key drivers of liver cancer. Some types of the human papillomavirus, which spreads through sexual contact, are responsible for cervical cancer. The bacterium Helicobacter pylori, typically spread through contaminated food or water, can cause stomach ulcers and cancers.

The International Agency for Research on Cancer estimates that around 13% of cancers globally are directly caused by infections, as the chart shows.

They estimate that pathogens cause nearly all cases of certain types of cancer, like Kaposi's sarcoma and cervical cancer.

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Reposted by Jared Mayers, MD, PhD

Saloni @scientificdiscovery.dev · 23/12/2024

Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself!

A timeline titled "The Golden Age of Antibiotics" shows when each antibiotic drug class was first available for medical use, with example antibiotics labeled. Classes are color-coded by their source: actinomycetes, other bacteria, fungi, or synthetic. Milestones include the first antibiotics (arsphenamines in 1910), as well as the discovery of many actinomycetes-derived antibiotics, such as streptomycin, and sulfonamides, penicillins, and tetracyclines. Data: Hutchings, Truman, Wilkinson (2019). Created by Saloni Dattani for Our World in Data.

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Reposted by Jared Mayers, MD, PhD

Célia Souque @celiasouque.bsky.social · 22/11/2024

Very glad to see this properly out and open access from my time with @baym.lol We've learnt so much about antibiotic resistance evolution already, and yet so many outstanding and fascinating questions remain, at all levels of selection. www.annualreviews.org/content/jour...

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Reposted by Jared Mayers, MD, PhD

Gabrielle Brewer @gabriellebrewer.bsky.social · 22/11/2024

More #NatureReviewsCancer updates 🚨 We recently launched a collection on the #microbiome in cancer. While its role is still debated, the collection presents a selection of articles from #SpringerNature journals to highlight our current understandings.🧫🦠 😀👉 bit.ly/48u8WFH

nature.com

The microbiome in cancer

The gut microbiome plays a crucial role in cancer development and progression, by influencing the host immune system and metabolism.

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