iiinova — where your digital self keeps evolving

Reposted by Josie Gleeson

Rob Patro @robp.bsky.social · 16/09/2026

bramble projects spliced genomic alignments into transcriptomic space. Any spliced genome alignments go in (tested with several, happy to add more if you find an incompatibility), a transcriptomic BAM comes out, salmon / oarfish / TranSigner carry on as normal. 📄 www.biorxiv.org/content/10.6...

biorxiv.org

Bramble: projection of spliced genomic alignments into transcriptomic space for improved transcript quantification

Accurate transcript abundance estimation is central to many transcriptomic studies. Many current quantification methods rely on reads mapped directly to the transcriptome, but transcriptome alignment ...

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Josie Gleeson @josiegleeson.bsky.social · 12/07/2026

Very happy to share our pre-print co-led with Nathan Andrews where we reveal splicing and isoform changes in a single-cell CRISPRi screen. For example, GEMIN5 knockdown produced minimal gene expression changes yet extensively reshaped the isoform landscape.

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Reposted by Josie Gleeson

New York Genome Center @nygenome.org · 25/03/2026

Congratulations to @tuuliel.bsky.social PhD, Senior Associate Faculty Member at the New York Genome Center, on receiving a prestigious award from the @eshg.bsky.social! Read more about this well-deserved recognition: www.nygenome.org/news-events/...

nygenome.org

Tuuli Lappalainen, PhD Receives Prestigious European Society of Human Genetics Award - March 25, 2026

Read about Tuuli Lappalainen, PhD Receives Prestigious European Society of Human Genetics Award at the New York Genome Center on March 25, 2026

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Reposted by Josie Gleeson

Mike Clark @michaelbclark.bsky.social · 17/12/2025

If you're studying #RNA transcript isoforms, check out IsoVis (the Isoform Visualiser webserver). isomix.org/isovis/ Recent updates now also allow visualisation of: 1. RNA modification sites and levels 2. Peptides mapping to open reading frames in isoforms and their abundances. 🧪

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Reposted by Josie Gleeson

SciLifeLab @scilifelab.se · 15/12/2025

Our call for 27 PULSE #postdocs is OPEN! PhD within the last 3 years looking to grow your life science career? SciLifeLab PULSE (MSCA Cofund) offers 3-year postdoc fellowships at Swedish universities with academic & industry secondments 🧪 🖥️ 🧬 📅 Apply Dec 15, 2025-Mar 16, 2026 👉 bit.ly/3MD7Pwz

A photo of a researcher looking into a microscope. On top of the photo, a text reading: "Apply now to the SciLifeLab PULSE Postdoc program. Application period open: December 15, 2025–March 16, 2026" and two logotypes: SciLifeLab's, and a version of the EU logotype reading "Co-funded by the European Union"

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Reposted by Josie Gleeson

Tuuli Lappalainen @tuuliel.bsky.social · 08/10/2025

We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here jobs.silkroad.com/NYGenome/Car...

jobs.silkroad.com

Postdoctoral Research Associate, Lappalainen & Sanjana Labs - 101 Avenue of the Americas, 7th Floor, New York, New York - New York Genome Center

Find a career with New York Genome Center

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Josie Gleeson @josiegleeson.bsky.social · 12/08/2025

Very excited to see our latest paper published!

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Reposted by Josie Gleeson

Tuuli Lappalainen @tuuliel.bsky.social · 05/05/2025

New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology. www.biorxiv.org/content/10.1...

biorxiv.org

Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits

Spatially resolved transcriptomics is transforming our understanding of cellular and molecular diversity of tissues. Here, to identify tissue structures that are enriched for putatively causal disease...

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