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Jonna Singh

@jonnasingh.bsky.social
760 followers 503 following 97 posts

Interoception, psychedelics, pain, flashy neurons, and everything in between prev basal ganglia and birds Postdoc @ Andermann lab

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Jonna Singh @jonnasingh.bsky.social · 26/08/2026
7/ In acute brainstem slices, we found a marker for spinorecipient neurons important for chronic pain. Our imaging prep also allowed us to ask whether inputs were likely to recruit specific cell types at the local (<50 um) scale w/ @crystianmassengill.bsky.social, @praneelsunkavalli.bsky.social
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Jonna Singh @jonnasingh.bsky.social · 26/08/2026
6/ In cortex, we found large scale cell-type specific differences in the spatial structure of correlated activity led by Josh Stern + Sarah Cook
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Jonna Singh @jonnasingh.bsky.social · 26/08/2026
4/ EASI-FISH is a protocol for iterative mRNA labeling in cleared, expanded *thick* tissue. While not required, we found that EASI-FISH is readily adoptable, and is a nice way to preserve 2P imaged planes in a single tissue sample EASI-FISH: pubmed.ncbi.nlm.nih.gov/34875226/
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Jonna Singh @jonnasingh.bsky.social · 26/08/2026
3/ Thus, EASI-PASS was created! EASI-PASS (EASI-FISH Post-hoc Alignment by Spatial Segmentation) uses segmented cell masks to guide 2P to post-hoc mRNA alignment. EASI-PASS matched ~40k neurons, is computationally cheap, scalable, and can be used with any pair of segmented images
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Jonna Singh @jonnasingh.bsky.social · 26/08/2026
2/ Our goal was to make an accessible, practical method that would allow more labs to measure neuronal activity and mRNA in the same neurons. Something easy to use, self-contained, and compatible with standard microscopes (confocals/2Ps)
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Jonna Singh @jonnasingh.bsky.social · 26/08/2026
We're excited to present EASI-PASS! We can record the activity of many neurons, and separately, the expression of many genes. A natural next step for the field is to link these two types of information. 🧵👇 1/n
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Jonna Singh @jonnasingh.bsky.social · 06/03/2026
1) Why is this the first I’m learning about fish talking to each other by slapping their bellies 2) The actual results in this paper are awesome
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Jonna Singh @jonnasingh.bsky.social · 17/11/2025
not easy to take a picture of a transparent object
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Jonna Singh @jonnasingh.bsky.social · 17/11/2025
Thanks @thetransmitter.bsky.social and to my lab for brightening my week with this rising stars in neuroscience award!! Wish I could be in #sfn to celebrate in the sun. Wonderful list of people: www.thetransmitter.org/early-career...
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Jonna Singh @jonnasingh.bsky.social · 17/06/2025
graphical abstract goes hard
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Jonna Singh @jonnasingh.bsky.social · 14/05/2025
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Jonna Singh @jonnasingh.bsky.social · 23/12/2024
peep the x axis😎
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Jonna Singh @jonnasingh.bsky.social · 15/12/2024
home today
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Jonna Singh @jonnasingh.bsky.social · 05/12/2024
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