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joneslabucsf.bsky.social @joneslabucsf.bsky.social · 07/10/2026

Can't wait to see everyone again and hear about all of the new, exciting discoveries🔬

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Bakar Aging Research Institute @ucsfaging.bsky.social · 06/10/2026

BARI spotlight: Hanna Marten’s review traces how matrix crosslinking, weak adhesions, and nuclear fragility feed senescence, and how that loop further degrades tissue mechanics. A clear case for resetting the aged mechanical niche. #aging #ECM journals.biologists.com/jcs/article/...

journals.biologists.com

The mechanisms and mechanics of aging

Summary: A Review of evidence suggesting that aging arises from progressive loss of mechanotransduction fidelity across the extracellular matrix (ECM)–cytoskeleton–nucleus axis, linking ECM remodeling...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 02/10/2026

BARI’s Dr. Kevan Shokat and colleagues in Nature: a design playbook for bitopic kinase inhibitors. Two grips on one kinase. Their ABL1 lead, PonatiLink-2, stays potent against resistance mutations and could be given at higher doses in mice without the toxicity seen with ponatinib.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 01/10/2026

BARI spotlight: Margaret Wallhagen co-authors a Nursing Outlook piece on why geroscience is richer with nurses as the table. Trusted messengers. Holistic care. A life-course view of aging. #nursing #geroscience www.nursingoutlook.org/article/S002...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 24/09/2026

New protocol from BARI’s Andrew Yang: isolate cerebral vessels, then pull high-purity nuclei for multi-omics. Blood-brain barrier cells are usually undercounted, this gives labs a clearer look at them. #neuroscience www.nature.com/articles/s41...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 23/09/2026

This week is Postdoc Appreciation Week and we’re grateful for the BARI postdocs who keep our science moving! You bring the experiments, the ideas, the late nights, and the questions that push aging biology forward. Thank you for being such a vital part of this community!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 22/09/2026

BARI spotlight: Kevan Shokat maps adaptive cell-cycle control in cancer and the emerging toolkit for CDK2 targeting. Useful reading for anyone thinking about kinase drugs after CDK4/6. #cancer www.nature.com/articles/s41...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 16/09/2026

BARI spotlight: Martin Kampmann’s group used genome-wide CRISPRi to find regulators of the interferon-responsive microglial state. Known interferon genes plus unexpected hits. A toolkit for asking when this program helps or harms the aging brain. #Microglia #aging bit.ly/4reK3az

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Bakar Aging Research Institute @ucsfaging.bsky.social · 15/09/2026

BARI’s Katrina Abuabara & team find higher estimated salt intake is associated with more IL-17-related inflammatory disease in ~470,000 UK Biobank participants, especially skin and joint conditions. Worth asking whether cutting salt could help. www.clinicalnutritionespen.com/article/S240...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 10/09/2026

Cool story from one of BARI’s newest members, Jason Gestwicki. Tau fibrils formed without cofactors are dynamic, and evolve over weeks unless agitation or polyanions stabilize them. A fresh look at how disease-specific tau folds may mature. pmc.ncbi.nlm.nih.gov/articles/PMC...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 08/09/2026

BARI spotlight: Martin Kampmann’s & team present a new CRISPR screen for genes that change how neurons depolarize. In human iPSC-derived neurons, they found known excitability players and disease genes not previously tied to firing. Excellent resource for the field. #Neuroscience #CRISPR

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Bakar Aging Research Institute @ucsfaging.bsky.social · 31/08/2026

New BARI member Reza Abbasi-Asl & colleagues find that daily step patterns, especially mid-day activity, reflect disability in progressive MS and can complement traditional clinic tests. Great use of wearable data! #MSResearch #wearables journals.sagepub.com/doi/10.1177/...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 28/08/2026

BARI spotlight: Jeanne Paz & colleagues report a new focal ischemic model of thalamic stroke that produces persistent spontaneous pain-like behavior in mice, closer to what many stroke survivors actually experience. An important new tool. #stroke #painresearch www.sciencedirect.com/science/arti...

sciencedirect.com

A focal ischemic stroke of the somatosensory thalamus produces persistent spontaneous pain–like behavior

Ischemic injury to the somatosensory ventrobasal (VB) thalamus is strongly associated with central post-stroke pain (CPSP), yet preclinical models of …

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Hiten Madhani @hitenmadhani.bsky.social · 27/08/2026

Most basic science departments at UCSF are having faculty searches this year. Biochemistry & Biophysics, Microbiology & Immunology, Cellular and Molecular Pharmacology, Physiology and more. We're looking for new and exciting science and nice people. You'll find them all at aprecruit.ucsf.edu

aprecruit.ucsf.edu

Welcome - AP Recruit

University of California, San Francisco Online Faculty Recruitment

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Kate Cavanaugh @katecavanaugh.bsky.social · 25/08/2026

And finally—a bit of personal news: 🔬 I’m on the faculty job market this year! I’m looking for tenure-track opportunities where I can build a lab at the intersection of developmental biology, mechanobiology, reproductive biology & aging.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 26/08/2026

Proud moment for BARI: Greg Bieri from the Villeda lab has been named a 2026 Simons Fellows-to-Faculty Awardee. This highly competitive program provides support to help outstanding postdocs transition to faculty positions.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 18/08/2026

Job alert from BARI! Seeking a passionate, highly motivated person to lead community building across our aging biology network. If you love connecting people and advancing the science of aging, this could be your role! Know someone perfect? Share or apply here: careers.ucsf.edu/careers/JobD...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 12/08/2026

New review! BARI’s Su Guo discusses how intranasal delivery offers a promising route to get therapies into the brain for Alzheimer's and Parkinson’s, but significant hurdles remain. Excellent overview of platforms, models, and computational tools. #Alzheimers #Parkinsons

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Bakar Aging Research Institute @ucsfaging.bsky.social · 07/08/2026

Big congrats to BARI’s John Greenland on this thoughtful ERJ Open Research editorial! Frailty improves for most lung transplant patients, especially those who start most frail, yet understanding which cases are driven by biology versus deconditioning could sharpen candidate selection and care.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 28/07/2026

Big congrats to BARI’s David Toczyski on this new paper in EMBO reports! His team uncovered how FBXO42 and CCDC6 keep protein phosphatase 4 under control, and why that matters for the survival of certain cancer cells. Beautiful mechanistic work that could open new doors! #cancerresearch #cellbiology

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Bakar Aging Research Institute @ucsfaging.bsky.social · 27/07/2026

Some chemical scaffolds just keep surprising us. New work from BARI’s Kevan Shokat shows that certain benzoxaboroles selectively bind the mRNA cap-binding pocket of eIF4E (a tough-to-drug proto-oncogene).

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Bakar Aging Research Institute @ucsfaging.bsky.social · 21/07/2026

How does a tiny zebrafish rebuild its tail after injury? One key player is a carefully timed shift in intracellular pH. New work from BARI’s Diane Barber shows that after tail amputation, cells first drop then raise their internal pH.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 16/07/2026

BARI spotlight: Isha Jain’s new study shows hypoxia can rescue a severe form of mitochondrial disease caused by protein quality control defects. In mice, it dramatically extends life, rescues striatal degeneration, and corrects the toxic tissue hyperoxia that arises when complex I becomes unstable.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 15/07/2026

Big congrats to BARI’s Peggy Cawthon and team on this new paper! Using radiomics on thigh CT scans, they tracked how subtle muscle ‘texture’ patterns change over 5 years in older adults, and found these patterns help explain shifts in strength and real-world function

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Bakar Aging Research Institute @ucsfaging.bsky.social · 14/07/2026

Ever wonder how a fish that lives just a few months could unlock secrets of aging and suspended animation? BARI’s Param Priya Singh just launched Killiverse: an interactive platform that brings together multi-omics data from killifish species like the African turquoise killifish.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 09/07/2026

Congrats to BARI’s Margaret Wallhagen on this thoughtful new review in The Gerontologist! Her team looked at what raises or lowers depression risk in older adults with vision loss and found that social support and good coping skills really help. Useful insights for supporting healthy aging!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 08/07/2026

Big congratulations to BARI’s Suneil Koliwad on this important JCI Insight paper! People with HIV show a distinct form of scarring in their body fat that drives insulin resistance and higher diabetes risk, even in those who are not obese. Real progress toward protecting metabolic health in HIV!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 07/07/2026

BARI spotlight: John Greenland’s new review beautifully links the origins of rapamycin on Easter Island to today’s innovative nanoparticle approaches for lung transplantation.

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joneslabucsf.bsky.social @joneslabucsf.bsky.social · 06/07/2026

Congratulations Roarke!! Well-deserved recognition for your innovative work🙌

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Bakar Aging Research Institute @ucsfaging.bsky.social · 25/06/2026

Big cheers for BARI’s Paul Wolter’s on this breakthrough! Telomere-stressed AT2 cells turn profibrotic early in lung fibrosis, p53 is the driver. Inhibiting it reverses damage, boosts healthy AT2 cells & halts fibrosis. Hopeful step toward better IPF therapies! academic.oup.com/ajrccm/artic...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 25/06/2026

Proud to highlight Christopher Hernandez’s review urging the field to target bone matrix quality for better fragility fracture prevention. Matrix mechanical properties matter as much as density, and they’re modifiable. A compelling case for new therapeutic strategies beyond current approaches.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 23/06/2026

BARI spotlight: Dena Dubal urges a shift in how we approach Alzheimer’s, recognizing women’s unique mix of vulnerability and resilience. Strong call for more research on female biology, sex-tailored care, and discoveries that help everyone age better. Important perspective! #Alzheimers #Womenshealth

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Bakar Aging Research Institute @ucsfaging.bsky.social · 18/06/2026

Check this out from BARI’s Kevan Shokat: Chai-1 deep learning makes crystal-quality models of covalent K-Ras complexes fast, accurate, and works great with covalent restraints for tough targets. Super useful for speeding up drug discovery! #Kras #drugdiscovery

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Bakar Aging Research Institute @ucsfaging.bsky.social · 17/06/2026

Big cheers for BARI’s Sarah Knox on this new iScience paper! Simple PBS rewetting restores damaged corneal stroma in autoimmune dry eye, fixing collagen, basement membrane & shifting keratocytes to reparative mode. Game-changer for dry eye! #opthalmology #dryeye www.cell.com/action/showP...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 16/06/2026

Big cheers for BARI’s Jayanta Debnath on this new Autophagy review! Membrane ATG8ylation helps cells secrete proteins, load EVs, and handle everything from metabolism to immune responses via clever non-degradative autophagy routes. Super interesting deep dive! pubmed.ncbi.nlm.nih.gov/42178909/

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Fusion Conferences @fusionconf.bsky.social · 15/06/2026

Our conference chairs @joneslabucsf.bsky.social & Ophir Klein are busy adding the final touches to the first draft of our #stemgastro programme! It's shaping up to be a fantastic meeting, don't delay in joining us in Mexico this November ➡️https://bit.ly/43wSRNZ

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Bakar Aging Research Institute @ucsfaging.bsky.social · 11/06/2026

Congratulations to BARI/Hillblom fellows Lea Baskin Monk, who received the ARCS Scholarship, and Yujie (York) Zhang, who received the Fletcher Jones Fellowship!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 11/06/2026

BARI’s celebrating Dengke Ma’s latest in Cell Reports! They uncovered how the ER guards itself against H2O2 with ERGU-1/TMEM161B, keeping protein folding smooth and supporting reproduction & stress responses. Outstanding discovery! pubmed.ncbi.nlm.nih.gov/42241275/

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Bakar Aging Research Institute @ucsfaging.bsky.social · 10/06/2026

BARI is celebrating Rushika Perera’s Molecular Cell study! They uncovered how pancreatic cancer cells use an autophagic capture complex to degrade ER-stalled MHC-I, reducing surface presentation. Links inefficient antigen loading and NFXL1 to immune escape. Beautiful work!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 05/06/2026

BARI is celebrating Andrew Yang’s Cell study! They developed genetic tracing to show brain protein clearance is regionally organized, with specialized border niches. Neuroinflammation and amyloid disrupt it differently, key for understanding neurodegeneration. Beautiful work!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 03/06/2026

Big cheers for BARI’s Katrina Abuabara on her new JAAD review! Atopic dermatitis is still diagnosed the old-fashioned way, history + exam + established criteria, but standardized tools make assessment clearer and care more consistent. Super practical guidance for clinicians!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 02/06/2026

BARI is celebrating Dengke Ma’s Nature Comms study! They found a simple way to trigger reversible suspended animation in worms using just crowded liquid conditions. Multi-omics, imaging, and genetics reveal how animals pause life and wake back up, fantastic work! #suspendedanimation

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Bakar Aging Research Institute @ucsfaging.bsky.social · 27/05/2026

Check out Max Krummel’s new Nature Immunology study: Comparing mouse and human tumor microenvironments, they highlight key differences in how these immune ecosystems assemble, plus conserved gene programs that track with patient outcomes. Excellent work and a handy new resource!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 26/05/2026

BARI is celebrating Kevan Shokat’s new ACS Chem Biol study! They designed long-acting CFTR potentiators by tweaking the protein-membrane interface, longer lipophilic chains dramatically extend activity via enhanced membrane retention. Exciting for CF and membrane drug design!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 21/05/2026

BARI is celebrating Dr. Dean Sheppard’s latest in Thorax! It shows circulating CTHRC1 is elevated in IPF patients and strongly linked to disease severity and survival, a clear reflection of the pathological fibroblasts driving fibrosis. Important step forward for better patient care.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 20/05/2026

Big cheers for BARI’s Michelle Arkin on her new PNAS paper! Molecular glues fix a key regulatory interaction in Noonan syndrome, restoring balance to MAPK signaling. This has real potential for targeted therapies for RASopathies! www.pnas.org/doi/10.1073/...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 13/05/2026

Nice work from BARI’s Martin Kampmann: In lab-grown neurons with an FTD-linked tau mutation, both the mutation and reducing tau led to shorter axons and changes in axon-related pathways.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 12/05/2026

Big congrats to BARI’s Todd Nystul and team on their new Aging Cell paper! As fruit fly ovaries age, the support cells that wrap and protect developing eggs start to fail, leading to poor egg packaging and built-up damage.

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