Sign in

Jonah Padawer-Curry, PhD

@jonahpadawercurry.bsky.social
120 followers 193 following 14 posts

Postdoctoral Fellow in the Satterthwaite lab | Studying brain dynamics and neuroimaging | Music after hours

PostsRepliesMedia
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 03/03/2026
Yet another phenomenal paper! @audreycluo.bsky.social is an absolutely star!
010 0
Reposted by Jonah Padawer-Curry, PhD
Joëlle Bagautdinova @joelleba.bsky.social · 05/01/2026
Ever wondered how white matter tracts actually map onto the cortical hierarchy and cognition—beyond the usual “projection vs association” labels? Our new preprint tackles exactly that! 🧠✨ doi.org/10.64898/202... Thread below 🧵
doi.org
Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity
Long-range white matter (WM) tracts support cognition by enabling communication between distant cortical regions, which are organized along a hierarchy defined by the sensorimotor-to-association (S-A)...
23315 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 13/11/2025
Earlier versions did! There are word limitations that make mentioning everything quite hard.
010 0
Reposted by Jonah Padawer-Curry, PhD
The Transmitter @thetransmitter.bsky.social · 29/10/2025
Psychedelics disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/psychedelics...
thetransmitter.org
Psychedelics muddy fMRI results: Q&A with Adam Bauer and Jonah Padawer-Curry
The drugs disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help…
13919 0
Reposted by Jonah Padawer-Curry, PhD
Brooke Sevchik @bsevchik.bsky.social · 12/11/2025
🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550 www.biorxiv.org/content/10.1...
14118 0
Reposted by Jonah Padawer-Curry, PhD
Nature Neuroscience @natneuro.nature.com · 22/10/2025
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of mouse and human brain function @adamqbauer.bsky.social @jordacular.bsky.social @realjoshsiegel.bsky.social @oliverk28.bsky.social www.nature.com/articles/s41...
nature.com
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function - Nature Neuroscience
Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI studies of psychedelics.
0114 0
Reposted by Jonah Padawer-Curry, PhD
Nature Portfolio @natureportfolio.nature.com · 18/10/2025
A study in Nature Neuroscience finds psychedelics disrupt the relationship between neuronal activity and blood flow in humans and mice. This suggests fMRI results under psychedelics may reflect vascular effects as much as neural ones and should be interpreted with caution. go.nature.com/47hqVPH 🧪
This image is figure 5 from the paper showing how hallucinogenic 5HT2AR agonism alters neurovascular coupling at local and global scales.
0316 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 16/10/2025
And the story continues to grow!!!
010 0
Reposted by Jonah Padawer-Curry, PhD
Alex Kwan @alexkwan.bsky.social · 01/08/2025
New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬 We found that psilocybin prolongs the neurovascular response, independent of neural activity. This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️
33812 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
And I want to thank the wonderful reviewers (among them was @theborislab.bsky.social )who made the paper all that much stronger
031 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
All of this work was made possible by the wonderful team. @AdamBauer @jordacular.bsky.social @realjoshsiegel.bsky.social @oliverk28.bsky.social @washumedicine.bsky.social @washumedmir.bsky.social
130 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
8/ So now what!? Next steps: • Validate in humans 🧍‍♂️ • Build “vascular correction” models • Revisit classic fMRI psychedelic studies
200 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
7/ Serotonin is vasoactive—it affects blood vessels, not just neurons (it’s right there in the etymology!). 🩸 Yet most imaging studies barely account for that.
100 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
6/ Take-home: neuronal and hemodynamic measures of brain function can dissociate under psychedelics, which has huge implications for interpreting human imaging data when under the influence of psychedelics.
110 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
5/ And here's a little mechanistic clue: blocking 5-HT₂A receptors (with MDL100907) predominantly reversed the dissociated reports of brain function → receptor-specific!?
100 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
4/ fMRI (BOLD) signals depend on blood flow. So, some “functional” effects in psychedelic imaging may reflect vascular—not neuronal—changes. We observe divergent patterns across multiple functional measures, including FC, modularity, power, and stimulus response ( @every figure)
120 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
3/ Even tripper: we saw similar shifts in human psilocybin fMRI data.
100 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
2/ After DOI (blue trace, right), neurovascular coupling (the link between brain ⚡️and blood 🩸signals) went off script. The hemodynamic response got tighter—and even sprouted an acausal feature (suggesting an emergent vasculo-neuronal relation!). Wild stuff. 🤯
100 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
1/ We concurrently tracked pan-cortical neural ⚡️and hemodynamic 🩸signals before and after psychedelic intoxication in mice. SURPRISE: these signals reported different effects!
100 0
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging
nature.com
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
14825 0