Signal peptides are highly variable, yet the signal peptidase complex processes them with remarkable specificity. Here, authors combine cryo-EM, molecular dynamics simulations and modeling to reveal a...

Water and its ability to modulate the protonation states of biomolecules govern the physical chemistry of life, dictating their metabolic functions...

Did you know that proteins lose bound waters upon acidification? We didn't as well. But we visualized this phenomenon in a series of high-resolution cryo-EM structures (~2 Å) across different pH value...

Water and its ability to modulate the protonation states of biomolecules govern the physical chemistry of life, dictating their metabolic functions. However, how amino acid protonation alters protein ...