Reposted by @jofoth.bsky.socialMichael Brockhurst @brockhurstlab.bsky.social · 06/10/20255-years in the making this paper has been a real journey! Also, a fun collaboration with @frimanscience.bsky.social @jofoth.bsky.social Edze Westra, Simon Lovell, Aras Kadioglu #mevosky #phagesky 163
Reposted by @jofoth.bsky.socialSiân Owen @sianowen.bsky.social · 28/05/2025Phage DisCo! Our targeted phage discovery method in press today: journals.asm.org/doi/10.1128/... Perfectly timed with our four summer undergrad's first successful phage hunt... disco lights in the lab to mark the occasion 🕺 69439
Reposted by @jofoth.bsky.socialEmmanuele Severi @emmseveri.bsky.social · 18/06/2025#phagesky www.cell.com/trends/micro...cell.comPhage tRNAs: decoding the enigmaThe presence of tRNAs in bacteriophage genomes has intrigued scientists since their discovery in the early 1960s, as phages were believed to rely on the host tRNAs for their translation. Over the year... 021
Reposted by @jofoth.bsky.socialMeaghan Castledine @mcastd.bsky.social · 23/06/2025New phage therapy publication!🦠 #phagesky We analysed an MRSA phage therapy case study, assessing how predictions made in vitro differed when using one (standard practice) or multiple bacteria isolates from the patient. Collaborative work: Exeter and Queen Astrid hospital doi.org/10.1093/jamb...doi.orgPredicting clinical phage therapy outcomes in vitro: results using mixed versus single isolates from an MRSA case studyAbstractAims. In phage therapy case studies, 1–3 bacteria isolates are typically tested against phages (phagogram). However, as bacteria populations differ 2159
Reposted by @jofoth.bsky.socialJack A Gilbert @gilbertjacka.bsky.social · 23/06/2025New Consensus Statement in Nature Microbiology! Working with low-biomass microbiome samples? From deep subsurface rocks to human lungs, contamination is a major challenge. We offer field-to-data analysis guidelines to help keep your results clean. 📖 doi.org/10.1038/s415...doi.orgGuidelines for preventing and reporting contamination in low-biomass microbiome studies - Nature MicrobiologyIn this Consensus Statement, the authors outline strategies for processing, analysing and interpreting low-biomass microbiome samples, and provide recommendations to minimize contaminants. 04722
Reposted by @jofoth.bsky.socialSiân Owen @sianowen.bsky.social · 06/07/2025Whoa, F-pilus dependent phage MS2 whips off it's capsid before entry into the cell?? www.sciencedirect.com/science/arti... "Extracellular uncoating of bacteriophage MS2" #phageskysciencedirect.comExtracellular uncoating of bacteriophage MS2In the early stages of infection of its host, Escherichia coli, bacteriophage MS2 sheds its icosahedral protein capsid, after which the single-strande… 14011
Reposted by @jofoth.bsky.socialTrevor Lithgow @trevor-lithgow.bsky.social · 17/07/2025We have been working on ways to find #phage with long shelf-life and this one is a winner. 12 months freeze-thawing as much as you like, no loss of viability #phageSky #microSky rdcu.be/ewnzTrdcu.beHighly stable bacteriophages PIN1 and PIN2 have hallmarks of flagellotropic phages but infect immotile bacterianpj Viruses - Bacteriophages (phages) are viruses that kill bacteria, with potential as antibacterial agents in industrial settings, agriculture, and human health. Here, we identified two phages,... 1168
Reposted by @jofoth.bsky.socialEmmanuele Severi @emmseveri.bsky.social · 23/07/2025#phagesky www.biorxiv.org/content/10.1...biorxiv.orgTemperate phages enhance host fitness via RNA-guided flagellar remodelingBacterial flagella drive motility and chemotaxis while also playing critical roles in host-pathogen interactions, as their oligomeric subunit, flagellin, is specifically recognized by the mammalian im... 055
Reposted by @jofoth.bsky.socialVivek Mutalik @vivekmutalik.bsky.social · 23/07/2025#phage #phagesky 0104
Reposted by @jofoth.bsky.socialVivek Mutalik @vivekmutalik.bsky.social · 27/07/2025#phage #phagesky www.biorxiv.org/content/10.1...biorxiv.orgPRISM: A platform for illuminating viral dark matterThe exploration of bacteriophage diversity remains constrained by reliance on conventional plaque assays, which bias discovery toward phages that form visible plaques and propagate efficiently. The di... 0122
Reposted by @jofoth.bsky.socialRuairi Robertson @ruairirobertson.bsky.social · 12/09/2024💊 Antibiotics damage the gut barrier via impaired mucus production independently of the microbiota. A consideration for those using antibiotic induced depletion of the microbiome in mice www.science.org/doi/10.1126/sciadv.… 1137
Reposted by @jofoth.bsky.socialshampadaspkpd.bsky.social @shampadaspkpd.bsky.social · 03/12/2024 We're advertising a fully funded PhD to explore the PK-PD of Phage therapy being developed for the treatment of Cystic Fibrosis lung infections. The post is in the Department of Pharmacology and Therapuetics at the University of Liverpool. @livuni-ismib.bsky.social @jofoth.bsky.socialfindaphd.comExploring the PK-PD of Phage therapy being developed for the treatment of Cystic Fibrosis lung infections at University of Liverpool on FindAPhD.comPhD Project - Exploring the PK-PD of Phage therapy being developed for the treatment of Cystic Fibrosis lung infections at University of Liverpool, listed on FindAPhD.com 051
Reposted by @jofoth.bsky.socialEllie Rand @ellie-rand.bsky.social · 23/11/2024Phage DisCo can be further multiplexed with three bacterial strains in co-culture, and, when tested with characterized phages, the fluorescent signal shined! Maybe you can see where the disco ball comparison comes in here. 🪩 4/ 1114
Reposted by @jofoth.bsky.socialᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 25/11/2024a triangle 🔺 it’s a basic shape, but no bacteria is a triangle a clothes hanger, a slice of pizza, a dorito—all triangles just not bacteria 26111
Reposted by @jofoth.bsky.socialWillem van Schaik @wvschaik.bsky.social · 30/10/2024Please sign up, it will be fun! Open for all with an interest in AMR and genomics (in the UK and elsewhere). www.targetamr.org.uk (and please give @target-amr.bsky.social a follow!)targetamr.org.ukTargetAMR – Reducing AMR through Genomics 52223