Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

Neurons were long thought to depend primarily on glucose metabolism for ATP production. However, recent findings from three laboratories show neurons metabolise long-chain fatty acids as alternative f...

Throughout the world, peer review serves as the cornerstone of the scientific enterprise, providing rigorous quality control and building the confidence that underpins progress for both science and so...

Here the authors show that inhibition of host N-myristoyltransferase by IMP1088 reduces SARS-CoV-2, VSV and RSV infection across lung and nasal cells, through a Golgi-bypassing virion egress that disr...

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning and memory, but the mechanisms through which neuronal activity affects the brain’s lipid l...

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

Greda et al. show that sortilin and apolipoprotein E3 mediate import and utilization of long-chain fatty acids as a metabolic fuel in neurons after glucose restriction.

Tiesitkö, että aivot voivat käyttää rasvaa energianlähteenä? Lupaavat uudet tutkimustulokset osoittavat, että aivojen hermosolut voivat käyttää rasvaa ajattelun, liikkumisen ja muistamisen polttoainee...

The prize-winning discovery explains how the immune system attacks hostile infections, but not the body's own cells.

For as long as modern neuroscience has existed, one belief has stood largely unquestioned: the brain, our most energy-hungry organ,…

Did you know your brain can run on fat? Exciting new research has revealed that neurons in the brain can use fats as fuel—powering our thoughts, movements, and memories. This surprising discovery open...

Nature Metabolism - Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking...

Author summary To initiate their infection cycle, most viruses first need to enter their target cells, a process called endocytosis. In mammalian cells, endocytosis often involves a class of proteins ...