Sign in

Joe Frost

@joefrost.bsky.social
106 followers 219 following 0 posts

Postdoctoral immunologist MSKCC Rudensky lab Tregs and inflammation // previously iron and immunity at Drakesmith lab University of Oxford

PostsRepliesMedia
Reposted by Joe Frost
MRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 18/12/2025
#WIMMReads: A new #review in Nature Reviews Immunology by Hal Drakesmith and Joe N Frost explores how #iron shapes immune responses in infection inflammation and cancer. Read more 👇 #Immunology #Immunology #IronMetabolism #Infection @rdm.ox.ac.uk @drakesmith-lab.bsky.social @medsci.ox.ac.uk
nature.com
Iron and the immune system - Nature Reviews Immunology
Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...
043
Reposted by Joe Frost
Xiao Huang @drxiaohuang.bsky.social · 15/12/2025
Excited to share our new study, the paper is out today @cp-immunity.bsky.social! Not all Treg cells are the same. We identified two Treg cell subsets with opposing functions in colorectal cancer (CRC). 1/8
1178
Reposted by Joe Frost
drakesmith-lab.bsky.social @drakesmith-lab.bsky.social · 17/09/2025
It was fun to make this with our fabulous collaborators!
031
Reposted by Joe Frost
Alejandra Mendoza @thepenkpanther.bsky.social · 05/09/2025
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻‍♀️
science.org
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
0238
Reposted by Joe Frost
drakesmith-lab.bsky.social @drakesmith-lab.bsky.social · 23/06/2025
2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...
nature.com
Iron and the immune system - Nature Reviews Immunology
Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...
0165
Reposted by Joe Frost
drakesmith-lab.bsky.social @drakesmith-lab.bsky.social · 24/03/2025
Wonderful to see this out, a big effort led by Alexandra Preston and fun for the lab to do something new (and very very old); plus it’s only slightly iron-related! 😳😱😀 www.nature.com/articles/s41...
nature.com
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis - Nature Communications
Nprl3 controls erythroblast metabolism and is upregulated by α -globin enhancers sited within its introns. This arrangement couples metabolic and developmental control during erythropoiesis and may ex...
051