#LegacyContent: Clinical Implementation of Matched Tumor/Germline Sequencing Improves Accuracy of Tumor Genomic Profiling and Therapeutic Recommendations.
Free in the #OpenArchive: www.jmdjournal.org/article/S1525-15…
jmdjournal.org
Clinical Implementation of Matched Tumor/Germline Sequencing Improves Accuracy of Tumor Genomic Profiling and Therapeutic Recommendations
Genomic profiling of cancers informs diagnostic and prognostic classification and
aids in selection of targeted therapeutics. Targeted, next-generation sequencing of
cancer-specific genes is clinically feasible and enables comprehensive somatic reporting;
without a matched germline specimen, germline alterations can confound analyses of
the somatic profile and create uncertainty in interpretation. We report the validation
and implementation of optional matched tumor/germline sequencing in our...
