iiinova — where your digital self keeps evolving

Jim Zoladek @jimzphd.bsky.social · 25/04/2025

Merci beaucoup à la @sfvirologie.bsky.social pour ce prix et pour ces journées riches en belle science ❤️🦠 Vivement l'année prochaine à Toulouse

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Jim Zoladek @jimzphd.bsky.social · 28/03/2025

Congratulations! Such a nice study. What a year for the team 🎉

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Jim Zoladek @jimzphd.bsky.social · 21/03/2025

Thank you, Juan! I'm glad you enjoyed the read. I believe this small protein still has many secrets to reveal

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Jim Zoladek @jimzphd.bsky.social · 20/03/2025

Thanks for everyone involved in this study, and especially my great superviser who allowed all of this to happen @sebnisole.bsky.social ! 🎊 @irim-life.bsky.social

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Jim Zoladek @jimzphd.bsky.social · 20/03/2025

𝗪𝗵𝗲𝗿𝗲 𝗶𝘀 𝗠𝗜𝗧𝗗𝟭 𝗶𝗻𝗱𝘂𝗰𝗲𝗱 𝗯𝘆 𝗶𝗻𝘁𝗲𝗿𝗳𝗲𝗿𝗼𝗻? 🧠 Mouse data pointed to the 𝗯𝗿𝗮𝗶𝗻, so we tested human brain cells. Only microglia, the immune sentinels of the brain, showed interferon-driven MITD1 expression. 🚨 This makes 𝗠𝗜𝗧𝗗𝟭 𝗮 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗜𝗦𝗚, protecting the brain from flaviviruses

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Jim Zoladek @jimzphd.bsky.social · 20/03/2025

𝗛𝗼𝘄 𝗱𝗼𝗲𝘀 𝗠𝗜𝗧𝗗𝟭 𝗯𝗹𝗼𝗰𝗸 𝘃𝗶𝗿𝗮𝗹 𝗿𝗲𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻? 🧬 MITD1 overexpression forms cytoplasmic aggregates that deplete CHMP1B+4B, key ESCRT-III proteins. 🔬 PLA confirmed their recruitment to flavivirus replication factories. Knockdown of CHMP1B+4B hinders MITD1’s antiviral effect—proving a link

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Jim Zoladek @jimzphd.bsky.social · 20/03/2025

To uncover new host factors restricting flavivirus replication, we screened a library of >1,000 interferon-stimulated genes (ISGs) across multiple species. Among known antiviral ISGs, we found 𝗠𝗜𝗧𝗗𝟭, a never-described-as-antiviral-before factor, as a potent inhibitor of WNV, USUV, ZIKV & DENV

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Jim Zoladek @jimzphd.bsky.social · 20/03/2025

🚨 New study in @pnas.org ! 🚨 We identified MITD1, a brain-specific interferon-inducible factor that 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝘀 𝗳𝗹𝗮𝘃𝗶𝘃𝗶𝗿𝘂𝘀 𝗿𝗲𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻, including WNV, USUV, ZIKV & DENV. 🔗 Read the paper: www.pnas.org/doi/10.1073/... 👇 Thread with take-home messages below! #Virology #Flavivirus #Interferon

pnas.org

MITD1 is a brain-specific interferon-inducible factor that inhibits flavivirus replication | PNAS

West Nile virus (WNV) and Usutu virus (USUV) are closely related mosquito-borne neurotropic flaviviruses that share common transmission cycle and c...

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Reposted by Jim Zoladek

Sébastien Nisole 🦋 @sebnisole.bsky.social · 19/02/2025

Check our latest opinion piece, just out in @cp-trendsmicrobiol.bsky.social! We delve into how the antiviral RNase ISG20 targets viral RNA and how some viruses escape it. @irim-life.bsky.social @ciri-lyon.bsky.social www.cell.com/trends/micro...

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