iiinova — where your digital self keeps evolving

Reposted by Jim Notwell

Ellen Rim @ellenrim.bsky.social · 20/08/2025

Really excited to join Stanford ChemE this September! We'll engineer proteins in plant immune and hormone pathways, combining high-throughput directed evolution with ML. Our goal is to enhance climate stress resilience and disease resistance in crops: rim.stanford.edu

rim.stanford.edu

Harnessing synthetic biology to engineer resilient crops

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Reposted by Jim Notwell

Mike Dickison @adzebill.bsky.social · 01/02/2025

The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...

blog.archive.org

End of Term Web Archive – Preserving the Transition of a Nation | Internet Archive Blogs

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Reposted by Jim Notwell

Alexander Howard @alexanderhoward.bsky.social · 29/01/2025

I'm very excited to share my first graduate research project! Check out our preprint which describes how data generated with directed evolution can be used to model the phenotypic effects of naturally-evolved sequence variants. (1/11) www.biorxiv.org/content/10.1...

biorxiv.org

Combining Directed Evolution with Machine Learning Enables Accurate Genotype-to-Phenotype Predictions

Linking sequence variation to phenotypic effects is critical for efficient exploitation of large genomic datasets. Here we present a novel approach combining directed evolution with protein language m...

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Reposted by Jim Notwell

Diego del Alamo @delalamo.xyz · 18/01/2025

FYI the designed esmGFP is 58% identical to the most similar extant GFP sequence - hence "500 million years of evolution" - but nearly half of the novelty (the 42% unaligned part of the seq) is derived from one other protein. Originally caught by @btnaughton.bsky.social, source link in alt text

Alignment showing how two extant sequences account for 74% of the sequence of esmGFP

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Reposted by Jim Notwell

Derek Lowe @dereklowe.bsky.social · 05/01/2025

I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10)

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Reposted by Jim Notwell

Matthew Herper @matthewherper.bsky.social · 30/12/2024

I shared this story about Jimmy Carter on X last year. I'd like to put it here, too. It starts with a reporter's keepsake. These are the notes President Carter handed me after I met him at a $MRK event to celebrate the company's collaboration with the Carter Center to end river blindness. 1/8

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