Jesse Brown @jesseab.bsky.social · 25/11/2025Key finding 5: Sensory-association imbalance is a promising cognitive biomarker for prognosis/monitoring because 1) higher imbalance at baseline predicts accelerated cognitive decline and 2) functional biomarkers will likely show more dynamic response to treatment. 100
Jesse Brown @jesseab.bsky.social · 25/11/2025Key finding 4: Structure and function biomarker scores both contribute to cognitive impairment. 100
Jesse Brown @jesseab.bsky.social · 25/11/2025Key finding 3: Eigenmode analysis reveals reductions in gradient amplitude and phase, which we call collapse. Those disruptions that add up to observed FC differences. 100
Jesse Brown @jesseab.bsky.social · 25/11/2025Key finding 2: Hypo and hyperconnectivity appear as two sides of the same coin. Different atrophy patterns perturb specific functional gradients, in which anticorrelated network pairs are embedded. 120
Jesse Brown @jesseab.bsky.social · 25/11/2025Key finding 1: Sensory-association functional connectivity imbalance (SAI) appears in all syndromes. As atrophy increases, sensory connectivity weakens and association connectivity gets stronger. Did not expect this. 110
Jesse Brown @jesseab.bsky.social · 25/11/2025We mapped structure-function relationships in Alzheimer’s disease and frontotemporal dementia. This was a good cohort because the atrophy patterns collectively cover almost the entire brain. 110
Jesse Brown @jesseab.bsky.social · 15/09/2025Stimulating the LGN with ultrasound and real-time fMRI, this is cool. Ultrasound system for precise neuromodulation of human deep brain circuits. www.nature.com/articles/s41... 020
Jesse Brown @jesseab.bsky.social · 27/02/2024Enjoying this, giving me 1996 feels and hope for the next wave. 000