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Jesse Brown

@jesseab.bsky.social
343 followers 83 following 50 posts

Neuro + data scientist, building radiata.ai - better brain biomarkers.

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Jesse Brown @jesseab.bsky.social · 25/11/2025
Key finding 5: Sensory-association imbalance is a promising cognitive biomarker for prognosis/monitoring because 1) higher imbalance at baseline predicts accelerated cognitive decline and 2) functional biomarkers will likely show more dynamic response to treatment.
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Jesse Brown @jesseab.bsky.social · 25/11/2025
Key finding 4: Structure and function biomarker scores both contribute to cognitive impairment.
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Jesse Brown @jesseab.bsky.social · 25/11/2025
Key finding 3: Eigenmode analysis reveals reductions in gradient amplitude and phase, which we call collapse. Those disruptions that add up to observed FC differences.
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Jesse Brown @jesseab.bsky.social · 25/11/2025
Key finding 2: Hypo and hyperconnectivity appear as two sides of the same coin. Different atrophy patterns perturb specific functional gradients, in which anticorrelated network pairs are embedded.
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Jesse Brown @jesseab.bsky.social · 25/11/2025
Key finding 1: Sensory-association functional connectivity imbalance (SAI) appears in all syndromes. As atrophy increases, sensory connectivity weakens and association connectivity gets stronger. Did not expect this.
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Jesse Brown @jesseab.bsky.social · 25/11/2025
We mapped structure-function relationships in Alzheimer’s disease and frontotemporal dementia. This was a good cohort because the atrophy patterns collectively cover almost the entire brain.
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Jesse Brown @jesseab.bsky.social · 15/09/2025
Stimulating the LGN with ultrasound and real-time fMRI, this is cool. Ultrasound system for precise neuromodulation of human deep brain circuits. www.nature.com/articles/s41...
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Jesse Brown @jesseab.bsky.social · 27/02/2024
Enjoying this, giving me 1996 feels and hope for the next wave.
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