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Jess Orr

@jess0rr.bsky.social

Epithelial Stem Cell Biologist 🫁 UCL

Jess Orr @jess0rr.bsky.social · 24/06/2025

Grateful to receive the Fairbairn Award for this presentation and for the opportunity to learn and discuss new ideas and progress in the gene and cell therapy fields. @charitydebra.bsky.social @cureeb.bsky.social @goshcharity.bsky.social @royalsociety.org @uclchildhealth.bsky.social

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Jess Orr @jess0rr.bsky.social · 24/06/2025

Had a wonderful time at the @bsgct.bsky.social annual conference! I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.

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Reposted by Jess Orr

Journal of Cell Science @jcellsci.bsky.social · 17/04/2025

Yuki Ishii, @jess0rr.bsky.social Sam Janes, @robhynds.bsky.social @epicentr.bsky.social & team identify Wnt pathway activators as potential pro-regenerative therapies in their compound screen in human airway basal cells. journals.biologists.com/jcs/article/... journals.biologists.com/jcs/article/...

Graphs and micrographs investigating Wnt pathway activating compounds as promoters of airway basal cell proliferation.

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Reposted by Jess Orr

Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 14/04/2025

🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social! We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo. doi.org/10.1242/jcs....

doi.org

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.

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