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Jesper Madsen

@jespergrud.bsky.social
69 followers 223 following 7 posts

Associate Professor @ University of Southern Denmark. Computational Biologist working with ML to understand transcriptional and genetic regulation of metabolic disease.

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Jesper Madsen @jespergrud.bsky.social · 07/10/2025
Excited to share DeepDive, a generative model for disentangling covariate effects in snATAC-seq developed by the amazing @andreasfm.bsky.social. DeepDive enables deeper understanding of a dataset by separating the effects of known and unknown covariates. Here are some highlights. 1/6
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Reposted by Jesper Madsen
Ravnskjaer_lab @ravnskjaer-lab.bsky.social · 03/03/2025
Check out our latest paper now online at Cell Metabolism: Hepatic stellate cells regulate liver fatty acid utilization via plasmalemma vesicle-associated protein. Amazing work by Daniel, Jasmin, Christian, Peter, Oliver from @ravnskjaer_lab, and many more 🏆💐♥️ www.cell.com/cell-metabol...
cell.com
Hepatic stellate cells regulate liver fatty acid utilization via plasmalemma vesicle-associated protein
Hansen et al. show that the hepatic stellate cell-expressed plasmalemma vesicle-associated protein is required for the normal switch from carbohydrate to lipid utilization during fasting. This reveals...
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Jesper Madsen @jespergrud.bsky.social · 01/02/2025
Preprint alert! We used snRNA-seq on adipose tissue from a longitudinal cohort of people undergoing surgury-induced weight loss. True ATLAS team effort We found dramatic changes in immune and progenitor compartments. Give it a read and let us know what you think. www.biorxiv.org/content/10.1...
biorxiv.org
Single cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss
During sustained weight gain, human white adipose tissue undergoes dramatic remodeling that may compromise adipose tissue function and lead to obesity comorbidities such as cardiometabolic disease. Th...
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