Very pleased to share our latest published work on the role of the innate immune inflammasome adaptor ASC in promoting pancreatic cancer. Thanks to all in our multinational team!
pubmed.ncbi.nlm.nih.gov/41654528/
@saigenci.bsky.social
@natcomms.nature.com
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Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer - PubMed
Pancreatic ductal adenocarcinoma (PDAC) is driven by genetic alterations in the pancreatic epithelium (e.g., KRAS) coupled with dysregulated innate immunity that triggers tumor-promoting chronic inflammation. However, the identity of innate immune molecular regulators as therapeutic targets in PDAC …
