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Jacobo de la Cuesta-Zuluaga

@jdlcz.bsky.social

202 followers 303 following 23 posts

Microbiome 🦠 data science 📈 computational biology 💻 and other crazy stuff at the amazing Maier Lab in Tübingen. He/Him.

Jacobo de la Cuesta-Zuluaga @jdlcz.bsky.social · 14/09/2026

Just out! @kiranrpatil.bsky.social @lisamaierlab.bsky.social and I wrote about how compounds not considered antibiotics (pharmaceutical, dietary, industrial, agricultural) can still impact the #microbiome 🦠 and human #health nature.com/articles/s41575-026-01258-w @natrevgastrohep.nature.com

Diagram of how non-antibiotic chemicals (from food, drugs, industry, and farming) interact with gut bacteria. Left side lists each source with an example compound and its structure: carboxymethyl cellulose from diet, metformin from pharmaceuticals, perfluorooctanoic acid from industry, chlorpyrifos from agriculture. In the center, arrows connect host and microbiome in both directions, labeled "Pharmacoecology" and "Pharmacomicrobiomics." The right side shows six effects on bacteria: bioaccumulation, direct killing, growth inhibition, horizontal gene transfer, cross-sensitization, and cross-protection. Boxes along the bottom flag the variables that shape these outcomes: exposure timing and dose, host diet and physiology, and the microbiome's existing structure.

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Jacobo de la Cuesta-Zuluaga @jdlcz.bsky.social · 13/10/2024

#Medication 💊 can negatively affect our #microbiome🦠, but we obviously can't stop using meds. What can we do, then? In our latest article we review and discuss some of the current and future strategies to reduce microbiome damage ❤️‍🩹 @cmfi.bsky.social doi.org/10.1016/j.ti...

Figure from a scientific paper describing multiple strategies to reduce damage to the microbiome caused by the use of medications

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