iiinova — where your digital self keeps evolving

Reposted by James Pang

Alex Fornito @alexfornito.bsky.social · 28/06/2026

Interested in the principles shaping connectome architecture? See our latest in @cp-cell.bsky.social led by F Normand @nsb-lab.bsky.social A simple model using geometric eigenmodes captures cortical connectomes of different species. Paper: tinyurl.com/3r43spf5 Thread: tinyurl.com/vx74hp6u

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James Pang @jchrispang.bsky.social · 15/06/2026

Such a fun @ohbmofficial.bsky.social symposium on “Bridging species and scales”!! Was great to see a packed room. Thanks @k4tj4.bsky.social @JustineHansen @elimuller.bsky.social for joining 😁 #OHBM2026

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Reposted by James Pang

Australasian Cognitive Neuroscience Society @acnsau.bsky.social · 19/05/2026

Abstracts and registrations are now open for #NeuroAlliance2026 🧠 Submit your latest research for consideration as an oral or poster presentation at this landmark joint meeting of ANS, ACNS and BPA. Visit: neuroalliance26.eventsair.site/call-for-abs... Deadline: 22 July 2026, 23:59 AEST

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Reposted by James Pang

Australasian Cognitive Neuroscience Society @acnsau.bsky.social · 13/05/2026

Don't miss out on this fantastic webinar on 22 May 2026 organised by our ECRs! Establishing an identity and visibility is critical in academia across career stages, so please share widely. See link below for the free registration 👇

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Reposted by James Pang

Julia Sliwa @juliasliwa.bsky.social · 24/04/2026

🧠🐒🐼🐷🐭🐬🦁Last chance to register to the Comparative Brain Meeting, April 27–30 2026, @pasteur.fr and online. MRI, fossils, connectivity, behaviour Register: forms.gle/DekynBhj8YC4... Program: braintrees.github.io/ComparativeB... @k4tj4.bsky.social @institutducerveau.bsky.social @r3rt0.bsky.social

forms.gle

Comparative Brain Meeting

Let's meet and exchange about our projects and progress on comparative brain analyses – comparative data, tools, and ways to work together. The meeting will be hosted at Institut Pasteur, 28 Rue Du ...

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Reposted by James Pang

Alex Fornito @alexfornito.bsky.social · 26/01/2026

Our latest preprint on how regional cellular, molecular, and other forms of heterogeneity shape macroscopic wave dynamics is now out: www.biorxiv.org/content/10.6... For a full thread, see: x.com/_victorbarne...

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James Pang @jchrispang.bsky.social · 20/06/2025

If you’re attending #OHBM2025 and will be your first time visiting Brisbane, this is an amazing resource created by the student and postdoc group

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James Pang @jchrispang.bsky.social · 18/05/2025

Due to unforeseen circumstances, we've extended the deadline to apply for our Systems and Comp Neuro postdoc position by a week (new deadline: May 25)! 🥳 If you have experience in modelling brain dynamics &/or analysing (s, d, f)MRI, we want you! Please help spread the word 👇

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James Pang @jchrispang.bsky.social · 12/05/2025

Applications for our postdoc position closes in 6 days! (Deadline: May 18 11:55pm AEST) If you are interested in MRI, modelling of brain dynamics, and genetics in health, disease, or across evolution, we would love for you to join our team👇👇

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James Pang @jchrispang.bsky.social · 17/04/2025

The job is for at least two years, and we're looking for someone who can start before the end of the year. Job ad closes on May 28 (see link for details). DM or email me at james{dot}pang1@monash{dot}edu for further questions.

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James Pang @jchrispang.bsky.social · 17/04/2025

We are hiring! @aurinaarn.bsky.social and I are jointly looking for a talented Postdoc in Systems and Comp Neuro at Monash (AUS). If you like neuroimaging 🧠, comp models 💻, genetics 🧬, brain disorders 🤕, and/or evolution 🐵🐭, this could be the job for you!! careers.pageuppeople.com/513/cw/en/jo...

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James Pang @jchrispang.bsky.social · 03/02/2025

Send me some 🐷 brains to add to the library 😆😆

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Reposted by James Pang

Alessandro Gozzi @gozziale.bsky.social · 02/02/2025

Geometric influences on the regional organization of the mammalian brain (!) Great new work lead by James Pang, @alexfornito.bsky.social & star collaborators! www.biorxiv.org/content/10.1...

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James Pang @jchrispang.bsky.social · 03/02/2025

For anyone interested in using our methods, the paper's associated GitHub page will be released soon. In the meantime, check out the preprint's main text and supps for all the juicy details. Can also send a DM or email at james{dot}pang1{at}monash{dot}edu for more info. (15/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

We started this in 2021, so it has been a long 4 yr study! Big thanks to @alexfornito.bsky.social PRobinson @kevinaquino.bsky.social PLevi @dralexholmes.bsky.social MMarkicevic XShen TFunck NPalomero RKong @bttyeo.bsky.social JTiego MBellgrove @toddc.bsky.social ELake @drbreaky.bsky.social (14/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

In summary, this work points to a fundamental role that geometry plays not just in shaping brain function but also in its regional organization that is conserved across the mammalian species. (13/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

We find highly robust correspondence between model solutions vs geometric modes and model parcs vs geometric parcs, demonstrating that the reaction-diffusion process may represent a conserved developmental mechanism for establishing the regional organization of the brain. (12/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

We want to go further and provide mechanistic insights into why our geometric parcellations work so well. Hence, we go back to the initial motivation of this study and develop a computational model that mimics the reaction and diffusion of patterning molecules. (11/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

Fourth, we can even go to the individual level, only needing individual-specific cortical surfaces. (10/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

Third, the approach and homogeneity results are generalizable to non-neocortical structures such as subcortical and allocortical structures (i.e., HIP, AMY, THA, NAc, GP, PUT, CAU). (9/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

Second, thanks to the data in the beautiful study of Schwartz et al. (2023, Nat Comms), we show that we can generate parcs for 24 other mammalian species, covering the Primata, Scandentia, Dermoptera, Rodentia, and Lagomorpha orders. Most don't even have parcs to date! (8/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

The great thing about our approach is that it only requires T1w MRI, so it is highly generalizable! First, it is generalizable to mammals (macaque, marmoset, mousse neocortices), with superior homogeneity against 15 existing parcs across 114 FC and non-FC phenotypes. (7/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

We also find that the homogeneity of the geometric parcs remains superior across 242 non-FC cortical phenotypes, covering diverse properties of morphometry, microstructure, cytoarchitecture, metabolism, gene expression, chemoarchitecture, and fMRI task activations! (6/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

Focusing first on the human neocortex, we find that the geometric parcs produce regions that are more functionally homogeneous (FC based on 3 independent resting-state fMRI datasets) than those in nearly all 17 cortical parcs commonly used in the field. (5/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

Inspired by this equivalence, we use the geometric eigenmodes (which can be derived directly from T1w MRI) to develop a simple, hierarchical approach for generating a multiscale parcellation of any brain structure. We term as geometric parcellations. (4/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

We know that patterning molecules (morphogens) are crucial for areal specification early in development. Interestingly, their expressions align with the rostrocaudal, mediolateral, and dorsoventral axes, corres. to low-order geometric modes. Image from O'Leary et al. (2017) (3/n)

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James Pang @jchrispang.bsky.social · 03/02/2025

Following our recent work showing how geometry constrains function (nature.com/articles/s41...), we ask whether geometry can also inform the regionalization of the brain. This is an important question as parcellations/atlases are fundamental to many aspects of neuroscience. (2/n)

nature.com

Geometric constraints on human brain function - Nature

Cortical and subcortical activity can be parsimoniously understood as resulting from excitations of fundamental, resonant modes of the brain’s geometry rather than from modes of complex interregional ...

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