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Jay Hesselberth

@jayhesselberth.bsky.social
509 followers 596 following 15 posts

RNA technologies. hesselberthlab.org

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Jay Hesselberth @jayhesselberth.bsky.social · 09/06/2026
This was part of the MIRA rationale. Figure 2 was from a Feedback Loop post from @jeremymberg.bsky.social www.molbiolcell.org/doi/10.1091/...
molbiolcell.org
Maximizing the return on taxpayers' investments in fundamental biomedical research | Molecular Biology of the Cell
The National Institute of General Medical Sciences (NIGMS) at the U.S. National Institutes of Health has an annual budget of more than $2.3 billion. The institute uses these funds to support fundament...
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Jay Hesselberth @jayhesselberth.bsky.social · 22/02/2026
Upset no one told me about Wild Pink. This would have been useful in 2025.
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Jay Hesselberth @jayhesselberth.bsky.social · 20/06/2025
I have been trying to onboard the 2A peptide pHMM models into Pfam to no avail. If anyone has a contact there, I would appreciate an introduction for a discussion. github.com/rnabioco/2a-...
github.com
GitHub - rnabioco/2a-peptide-search: HMM models of the 2A peptide and DB search results
HMM models of the 2A peptide and DB search results - rnabioco/2a-peptide-search
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Jay Hesselberth @jayhesselberth.bsky.social · 20/06/2025
This entire project would not have been possible with out HMMER. bsky.app/profile/cryp...
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Jay Hesselberth @jayhesselberth.bsky.social · 20/06/2025
Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class. www.cell.com/cell-reports...
cell.com
Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences
Rao et al. identified thousands of previously unknown 2A peptides across both viruses and eukaryotes using an HMMER analysis. The authors further identified a unique class of 2A peptides, class B, who...
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Jay Hesselberth @jayhesselberth.bsky.social · 11/03/2025
Any word on whether these are all NIAID grants? Or do they include neoepitope mRNA vaccine studies funded by NCI, etc?
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Jay Hesselberth @jayhesselberth.bsky.social · 20/02/2025
In my experience REPORTER is not updated in real-time. Not sure it's a reliable measure of the effect.
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Jay Hesselberth @jayhesselberth.bsky.social · 13/02/2025
I just updated this R data package for NIH EXPORTER data. Can you file an issue with your approach for calculating ICR? github.com/rnabioco/nih...
github.com
GitHub - rnabioco/nihexporter: An R data package for NIH EXPORTER data
An R data package for NIH EXPORTER data. Contribute to rnabioco/nihexporter development by creating an account on GitHub.
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Jay Hesselberth @jayhesselberth.bsky.social · 09/02/2025
Just released an update of an R data package for NIH funding data from 1985-2024. github.com/rnabioco/nih...
github.com
GitHub - rnabioco/nihexporter: An R data package for NIH EXPORTER data
An R data package for NIH EXPORTER data. Contribute to rnabioco/nihexporter development by creating an account on GitHub.
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Jay Hesselberth @jayhesselberth.bsky.social · 09/02/2025
I maintain an R data package of NIH EXPORTER data. Updated last week. github.com/rnabioco/nih...
github.com
GitHub - rnabioco/nihexporter: An R data package for NIH EXPORTER data
An R data package for NIH EXPORTER data. Contribute to rnabioco/nihexporter development by creating an account on GitHub.
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Jay Hesselberth @jayhesselberth.bsky.social · 08/02/2025
And I forgot the default REPORTER search only lists active grants. This list is pretty long.
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Jay Hesselberth @jayhesselberth.bsky.social · 08/02/2025
Technically speaking, your last point is incorrect. (but the NIH REPORTER link doesn't go anywhere useful to confirm this is the same person; I inferred it from the abstract)
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Jay Hesselberth @jayhesselberth.bsky.social · 19/11/2024
This is on a (very long) to-do list.
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Jay Hesselberth @jayhesselberth.bsky.social · 19/11/2024
Also crossing "publish with your scientific grandfather" off my bucket list.
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Jay Hesselberth @jayhesselberth.bsky.social · 19/11/2024
Here for my first post. Our new approach to study tRNA aminoacylation by nanopore sequencing. Started as a napkin sketch ~1 year ago! This was a fun one, congrats to @laurakwhite.bsky.social and Aleks. www.biorxiv.org/content/10.1...
biorxiv.org
Nanopore sequencing of intact aminoacylated tRNAs
Transfer RNAs (tRNA) are decorated during biogenesis with a variety of modifications that modulate their stability, aminoacylation, and decoding potential during translation. The complex landscape of ...
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