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Lars Jansen Lab

@jansenlab.bsky.social

264 followers 60 following 13 posts

Discovering Mechanisms of Chromatin Inheritance at the University of Oxford www.jansenlab.org

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Lars Jansen Lab @jansenlab.bsky.social · 17/05/2026

Just returned from an incredible 3-day multi-lab retreat with the teams of Daniele Fachinetti, Nick @naltemose.bsky.social, and Dominika Gruszka in Pêra, Portugal. Sunshine😎, great company 🤗 and fantastic centromere and chromatin science 🔬! Thanks to all the teams for this wonderful gathering!

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Lars Jansen Lab @jansenlab.bsky.social · 30/12/2025

I love running into random street biochemistry!

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Lars Jansen Lab @jansenlab.bsky.social · 25/11/2025

SETDB1, previously implicated in transposon silencing, is a novel player in maintaining heterochromatin boundaries within core alpha satellites. This regulation is critical, as loss of heterochromatin integrity results in ectopic CENP-A domains and distal centromere nucleation!

new CENP-A domains are seeded in heterochromatin mutants

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Lars Jansen Lab @jansenlab.bsky.social · 25/11/2025

A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration. www.nature.com/articles/s41...

differential contribution of H3K9 methyltransferases to boundaries at satellites

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Lars Jansen Lab @jansenlab.bsky.social · 29/07/2025

The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years! Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out. link.springer.com/article/10.1...

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Lars Jansen Lab @jansenlab.bsky.social · 04/04/2025

Fresh of the press! rdcu.be/egmY0 We discovered key chromatin modifications that are heritably maintained through mitotic cell divisions in the absence of continued transcription. These hold a memory of past exposure to interferon-gamma, priming cells for future activation of gene expression.

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Lars Jansen Lab @jansenlab.bsky.social · 05/02/2025

@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...

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Lars Jansen Lab @jansenlab.bsky.social · 17/12/2024

Join our team www.jansenlab.org as a @wellcometrust.bsky.social -funded postdoctoral fellow and help us discover how chromatin at human centromeres is formed and inherited. Position now open at @oxfordbiochemistry.bsky.social! See: my.corehr.com/pls/uoxrecru... for details!

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