iiinova — where your digital self keeps evolving

Jana Fuhrmann @janafuhrmann.bsky.social · 06/05/2026

Such a cool story. Congrats Ali!

Reposted by Jana Fuhrmann

paveltomancak.bsky.social @paveltomancak.bsky.social · 04/09/2025

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

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Reposted by Jana Fuhrmann

natalieadye.bsky.social @natalieadye.bsky.social · 18/02/2025

I'm looking for a talented+motivated person to join my team at the #MechanobiologyInstitute @NUS for a #postdoc. If you're interested in investigating collective cell behavior during 3D tissue #morphogenesis with me, please apply here or PM for Qs. Please RT! careers.nus.edu.sg/job/Research...

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

and not many authors yet on Bluesky except of course the fabulous @natalieadye.bsky.social

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

Taken together we show that 3D epithelial tissue morphogenesis in the Drosophila wing disc pouch during eversion is based on in-plane spontaneous strains generated by active cellular behaviours, and propose that this could be a more general mechanism for shaping animal tissues. - The End - 11/11

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

We test the model, by perturbing MyoVI, for which we previously showed that it disrupts mechanosensitive feedback and probably affects oriented rearrangements. And we nailed it. 10/n

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

Using this model we found, that radial rearrangements and an inhomogeneous increase in cell area drive the shape change in the wing disc. This supports the idea of a mechanical pre-patterning because the cell area distribution and the radial bias in rearrangements arise from earlier stages. 9/n

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

To test the observed cell behaviours we build a 'simple' computational model based on a network of interconnected springs, in which - by a change in spring length - we can impose different measured deformations. 8/n

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

So how did we test this? We quantified the tissue shape change and cell shapes at different time points, and identified patterns of cell shapes using a topological coordinate system. Using topology also allowed us to infer the amount of oriented rearrangements from static images. 7/n

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

In our case, it means that the material (aka the tissue) undergoes pre-defined (genetics/ mechanics), local (the cells), in-plane (in the plane of the cell sheet) deformations, that create a tissue-wide geometric incompatibility with the initial shape (going from flat to curved). 6/n

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

So how do you get such a complex shape change? To answer this, we took inspiration from Material Sciences, more specifically from 'shape programmable materials'. These materials experience spontaneous strains, where the internal lengths change in response to stimuli in a desired way. 5/n

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

Why is this interesting? First, eversion is a large-scale (hundreds of cells) tissue shape change. Second, it is complex, as it undergoes curvature changes in different directions (unlike, for example, a one-directional change as in folding), and it is not radially symmetric (tubes, budding). 4/n

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

At the transition from larva to pupa, the wing disc undergoes a 3D shape change called wing eversion. Which we studied, focusing on the shape change of a subregion, the wing disc pouch (here in blue/grey). 3/n

A 3D segmentation of the wing disc in different views before and during eversion. Highlighting a dramatic shape change from dome-like to bi-layered.

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

In this paper, we tackle the 3D epithelial shape changes during Drosophila wing disc eversion. Wing what? - Briefly: Drosophila has different live phases: Embryo, Larva, Pupa and Adult. The future adult wing arises from the wing disc, which grows and morphs throughout the live of the fly. 2/n

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Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024

I love seeing so many interesting papers on Bluesky and my reading list keeps growing. So I would like to share a thread about our paper from this year. It was published when we were still at *the other place*, and I didn't feel like writing about it there. www.science.org/doi/full/10.... 1/n

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